Toxicological Effects of Technical Xylene Mixtures on the Female Reproductive System: A Systematic Review

IF 4.1 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Toxics Pub Date : 2022-05-01 DOI:10.3390/toxics10050235

N. Suaidi, M. Alshawsh, S. Hoe, M. H. Mokhtar, Siti Rosmani Md Zin

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引用次数: 1

Abstract

Technical xylene is a compound of massive production that is used in applications such as petrochemical and healthcare laboratories. Exposure to xylene can cause acute and chronic effects in humans and animals. Currently available studies regarding xylene’s adverse effects with credible designs were dated almost twenty years ago. This systematic review summarizes the findings regarding the detrimental effects of technical xylene from human, animal, and in vitro studies. It recapitulated available studies with respect to the effects of xylene on the female reproductive system to stress the need for updating the current data and guidelines. Based on pre-specified criteria, 22 studies from journal databases exploring the toxic effects of xylene on menstruation, endocrine endpoints, fetal development, and reproductive functions were included for the review. It was found that related studies with a specific focus on the effects of technical xylene on the female reproductive system were insufficient. Therefore, further studies are necessary to update the existing data, thus improving the quality and reliability of risk assessment of exposure to xylene in pregnant women

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技术性二甲苯混合物对雌性生殖系统的毒理学影响：系统评价

工业二甲苯是一种大规模生产的化合物，用于石化和医疗实验室等应用。接触二甲苯会对人类和动物造成急性和慢性影响。目前可用的关于二甲苯不良反应的可靠设计的研究可以追溯到近20年前。这篇系统综述总结了人类、动物和体外研究中有关工业二甲苯有害影响的发现。它概述了关于二甲苯对女性生殖系统影响的现有研究，强调需要更新现有数据和指南。根据预先指定的标准，来自期刊数据库的22项研究探讨了二甲苯对月经、内分泌终点、胎儿发育和生殖功能的毒性影响，纳入了该综述。研究发现，专门关注工业二甲苯对女性生殖系统影响的相关研究不足。因此，有必要进一步研究以更新现有数据，从而提高孕妇接触二甲苯风险评估的质量和可靠性

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来源期刊

Toxics Chemical Engineering-Chemical Health and Safety

CiteScore

4.50

自引率

10.90%

发文量

681

审稿时长

6 weeks

期刊介绍： Toxics (ISSN 2305-6304) is an international, peer-reviewed, open access journal which provides an advanced forum for studies related to all aspects of toxic chemicals and materials. It publishes reviews, regular research papers, and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in detail. There is, therefore, no restriction on the maximum length of the papers, although authors should write their papers in a clear and concise way. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of calculations and experimental procedure can be deposited as supplementary material, if it is not possible to publish them along with the text.