Recent progress in alginate-based carriers for ocular targeting of therapeutics

IF 4.6 Q1 CHEMISTRY, APPLIED Food Hydrocolloids for Health Pub Date : 2022-12-01 DOI:10.1016/j.fhfh.2022.100071
Sandip Karmakar , Sreejan Manna , Sourav Kabiraj , Sougata Jana
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引用次数: 17

Abstract

Eye is one of the susceptible organs of the human body which is associated with several internal organs including the brain. Due to the protective mechanisms of body and ocular barrier properties, the area of ocular drug delivery presents a challenge to pharmaceutical researchers. Alginate is a naturally occurring polysaccharide obtained from marine brown seaweeds and bacterial sources. According to the Food and Drug Administration, (FDA) alginate is generally recognized as safe (GRAS). It is widely used as a gelling agent and thickener in the food industries. In the field of drug delivery, alginate is extensively investigated as an excipient. In ocular targeting of therapeutics, sodium alginate offers many advantages including ion sensitive in situ gelation, non-toxic and biodegradable behaviour in combination with mucoadhesive nature of the polymer. The instant gelation ability of alginate allows it to increase the ocular residence time and enhances the ocular drug bioavailability reducing the requirement of frequent administration of drug. The abundant availability and attractive physicochemical properties of alginate has encouraged pharmaceutical scientists to explore newer strategies in ocular drug targeting. In this review, the efficacy of alginate in delivering various therapeutic agents has been discussed.

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以海藻酸盐为基础的眼部靶向治疗载体的研究进展
眼睛是人体的易感器官之一,它与包括大脑在内的几个内脏器官都有联系。由于机体和眼屏障特性的保护机制,眼内给药成为药学研究的一个挑战。藻酸盐是一种天然存在的多糖,从海洋棕色海藻和细菌来源中获得。根据美国食品和药物管理局(FDA),海藻酸盐通常被认为是安全的(GRAS)。在食品工业中广泛用作胶凝剂和增稠剂。在给药领域,海藻酸盐作为一种赋形剂被广泛研究。在眼部靶向治疗中,海藻酸钠具有许多优点,包括离子敏感的原位凝胶,无毒和可生物降解的行为,以及聚合物的黏附性。海藻酸盐的即时凝胶能力使其能够增加眼部停留时间,提高眼部药物的生物利用度,减少频繁给药的需要。海藻酸盐丰富的可用性和吸引人的理化性质促使药理学家探索眼部药物靶向治疗的新策略。本文综述了海藻酸盐在各种治疗药物输送中的作用。
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61 days
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