A clinical case of the debut of pemphigus foliaceus against the background of vaccination against coronavirus infection (COVID-19)

Q4 Medicine Vestnik dermatologii i venerologii Pub Date : 2022-11-01 DOI:10.25208/vdv1336
V. Vlasova, Martynov Martynov, Svischenko Svischenko
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Abstract

The article describes the onset of pemphigus foliaceus against the background of vaccination with the combined vector vaccine "Gam-COVID-Vac" ("Sputnik V"). A feature of this clinical case is the duration of the period from the moment of development of the first symptoms of the disease to clinical and immunohistochemical confirmation of the diagnosis, which, in fact, indicates a low availability of specialized medical care for rare dermatoses. In particular, the waiting period for taking material for histological examination lasted for several months, which, in fact, is not an isolated case. At the same time, against the background of an increase in clinical symptoms, this became an additional factor in the patient's self-referral to a specialized federal state medical institution, where, within two weeks, the diagnosis was confirmed by immunohistochemical analysis methods and inpatient treatment was carried out with a pronounced positive effect. In addition, the analysis of the medical care provided to the patient showed insufficient alertness and the level of training of dermatovenereologists in diagnosing rare dermatoses accompanied by blistering rashes. In particular, the patient initially underwent several courses of antifungal therapy in combination with intravenous infusion of systemic glucocorticosteroids. The article also presents an analysis of the frequency of occurrence of this disease in different countries for more than 100 years.
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在接种冠状病毒感染疫苗(新冠肺炎)的背景下首次出现叶片天疱疮的临床病例
这篇文章描述了在联合载体疫苗“Gam-COVID-Vac”(“Sputnik V”)接种的背景下,叶面天疱疮的发病情况。这种临床病例的一个特点是,从出现疾病的第一个症状到临床和免疫组织化学确认诊断的持续时间,这实际上表明罕见皮肤病的专业医疗服务的可用性很低。特别是,取材料进行组织学检查的等待期持续了几个月,事实上,这并不是一个孤立的案例。与此同时,在临床症状增加的背景下,这成为患者自行转诊到联邦-州专业医疗机构的一个额外因素,在那里,在两周内,通过免疫组织化学分析方法确认了诊断,并进行了住院治疗,取得了显着的积极效果。此外,对向患者提供的医疗护理的分析显示,皮肤性病学家在诊断罕见皮肤病并伴有起泡皮疹方面的警觉性和培训水平不足。特别是,患者最初接受了几个疗程的抗真菌治疗,并联合静脉输注全身糖皮质激素。文章还分析了100多年来这种疾病在不同国家的发生频率。
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来源期刊
CiteScore
0.80
自引率
0.00%
发文量
40
审稿时长
8 weeks
期刊最新文献
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