Injectable bioactive glass-based pastes for potential use in bone tissue repair

Q1 Materials Science Biomedical Glasses Pub Date : 2020-01-01 DOI:10.1515/bglass-2020-0003

D. Tulyaganov, A. Akbarov, N. Ziyadullaeva, Bekhzod Khabilov, F. Baino

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引用次数: 4

Abstract

Abstract In this study, injectable pastes based on a clinically-tested bioactive glass and glycerol (used as organic carrier) were produced and characterized for further application in regenerative medicine. The paste preparation route, apatite-forming ability in simulated body fluid (SBF) solution, viscoelastic behavior and structural features revealed by means of scanning electron microscopy (SEM), FTIR and Raman spectroscopy were presented and discussed, also on the basis of the major experimental data obtained in previous studies. A mechanism illustrating the chemical interaction between bioactive glass and glycerol was proposed to support the bioactivity mechanism of injectable pastes. Then, the results of In vivo tests, conducted through injecting moldable paste into osseous defects made in rabbit’s femur, were reported. Animal studies revealed good osteoconductivity and bone bonding that occurred initially at the interface between the glass and the host bone, and further supported the suitability of these bioactive glass pastes in bone regenerative medicine.

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可注射生物活性玻璃基糊剂在骨组织修复中的潜在用途

摘要在本研究中，基于临床测试的生物活性玻璃和甘油（用作有机载体）制备并表征了可注射糊剂，以进一步应用于再生医学。在前人研究的主要实验数据的基础上，介绍并讨论了糊剂的制备路线、模拟体液（SBF）溶液中磷灰石的形成能力、扫描电子显微镜（SEM）、傅立叶变换红外光谱（FTIR）和拉曼光谱（Raman spectroscopy）揭示的粘弹性行为和结构特征。提出了一种阐明生物活性玻璃与甘油之间化学相互作用的机制，以支持可注射糊剂的生物活性机制。然后，报告了通过将可成型糊剂注射到兔股骨骨缺损中进行的体内试验的结果。动物研究表明，良好的骨传导性和骨结合最初发生在玻璃和宿主骨之间的界面，并进一步支持了这些生物活性玻璃糊剂在骨再生医学中的适用性。

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来源期刊

Biomedical Glasses Materials Science-Surfaces, Coatings and Films

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0.00%

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审稿时长

17 weeks

期刊介绍： Biomedical Glasses is an international Open Access-only journal covering the field of glasses for biomedical applications. The scope of the journal covers the science and technology of glasses and glass-based materials intended for applications in medicine and dentistry. It includes: Chemistry, physics, structure, design and characterization of biomedical glasses Surface science and interactions of biomedical glasses with aqueous and biological media Modeling structure and reactivity of biomedical glasses and their interfaces Biocompatibility of biomedical glasses Processing of biomedical glasses to achieve specific forms and functionality Biomedical glass coatings and composites In vitro and in vivo evaluation of biomedical glasses Glasses and glass-ceramics in engineered regeneration of tissues and organs Glass-based devices for medical and dental applications Application of glasses and glass-ceramics in healthcare.