Phytochemical and neuroprotective evaluation of Citrus aurantium essential oil on cerebral ischemia and reperfusion

IF 0.9 4区医学 Q4 PHARMACOLOGY & PHARMACY Bangladesh Journal of Pharmacology Pub Date : 2018-12-07 DOI:10.3329/BJP.V13I4.37408

Arezo Sadeghimanesh, V. Khalaji-Pirbalouty, Z. Lorigooini, M. Rafieian-kopaei, A. Torki, Z. Rabiei

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引用次数: 3

Abstract

This study was conducted to investigate the neuroprotective effect of Citrus aurantium essential oil on hippocampal injury induced by transient global cerebral ischemia and reperfusion in rat. In total 50 rats were randomly assigned into five groups; control, sham, ischemia, and essential oil-treated (50 or 75 mg/kg) rats. Ischemia was induced by occlusion of the carotid artery for 30 min. Spatial memory, passive avoidance learning, anti-oxidant capacity, and lipid peroxidation during ischemia/reperfusion were evaluated. The compounds of the essential oil were analyzed by gas chromatography/mass spectrometry. Induction of ischemia/reperfusion caused a decline in learning and passive avoidance memory in rats. C. aurantium exerted protective effects on the spatial memory, passive avoidance learning, anti-oxidant capacity, and lipid peroxidation during ischemia/reperfusion in animals. The main compounds of the essential oil were camphor (45.9%), thymol (11.2%), linalool (6.6%), carvacrol (6.3%) and borneol (2.9%). The essential oil with anti-oxidant compounds significantly decreased the symptoms of ischemia/reperfusion injury.

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柑桔精油对脑缺血再灌注的植物化学和神经保护作用评价

本研究旨在探讨柑桔精油对大鼠短暂性全脑缺血再灌注海马损伤的神经保护作用。50只大鼠随机分为5组;对照大鼠、假手术大鼠、缺血大鼠和精油处理大鼠(50或75 mg/kg)。闭塞颈动脉30分钟，观察缺血/再灌注时空间记忆、被动回避学习、抗氧化能力和脂质过氧化的变化。采用气相色谱/质谱联用技术对挥发油的成分进行分析。缺血再灌注诱导大鼠学习记忆和被动回避记忆功能下降。金对动物缺血/再灌注时的空间记忆、被动回避学习、抗氧化能力和脂质过氧化有保护作用。精油的主要成分为樟脑(45.9%)、百里酚(11.2%)、芳樟醇(6.6%)、香芹酚(6.3%)和冰片(2.9%)。含有抗氧化成分的精油可明显减轻缺血再灌注损伤的症状。

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来源期刊

Bangladesh Journal of Pharmacology PHARMACOLOGY & PHARMACY-

CiteScore

1.50

自引率

18.80%

发文量

审稿时长

>12 weeks

期刊介绍： Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, peer-reviewed journal of the Bangladesh Pharmacological Society (BDPS). A scholarly publication is defined ''open access'' when there are no financial, legal or technical barriers to accessing it. Anyone can read, download, copy, distribute, print or use it in educational purpose within the legal agreements. Peer review of a manuscript means the evaluation of research work by one or more people with similar competences. It can be open or blind. We do the single-blind peer review. Our readers want to know the methodology used by the researchers which is very important to get the results. The video clip of one of the methodologies is prepared by the authors and submit it to publish.