{"title":"Neuraminidase / sialidase from influenza virus: its characteristics, nomenclature, measuring of activity, kinetics, inhibitors as therapeutic agents","authors":"José Antonio Cabezas Fernández del Campo","doi":"10.53519/analesranf.2022.88.05.07","DOIUrl":null,"url":null,"abstract":"The main characteristics of neuraminidase / sialidase from Influenza Virus and its peculiar nomenclature are described, as well as two new, sensitive and simple procedures (fluorometric and by luminiscence) for measuring neuraminidase activity, which have been used at the Department of Biochemistry and Molecular Biology of the University of Salamanca (Prof. J. A. Cabezas). The kinetics of neuraminidase of three A and three B Influenza Virus Strains, and the result of the comparison of biological and physical properties of human and animal origin (pig and duck) Virus Strains, belonging to the same subtype A(H1N1), are described. Finally, the advantages and risks for the use as therapeutic agents against Influenza of the Influenza Virus neuraminidase inhibitors Zanamivir, Oseltamivir and Peramivir are discussed.\n\nKeywords: neuraminidase / sialidase; influenza virus; inhibitors","PeriodicalId":50795,"journal":{"name":"Anales De La Real Academia Nacional De Farmacia","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Anales De La Real Academia Nacional De Farmacia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.53519/analesranf.2022.88.05.07","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 0
Abstract
The main characteristics of neuraminidase / sialidase from Influenza Virus and its peculiar nomenclature are described, as well as two new, sensitive and simple procedures (fluorometric and by luminiscence) for measuring neuraminidase activity, which have been used at the Department of Biochemistry and Molecular Biology of the University of Salamanca (Prof. J. A. Cabezas). The kinetics of neuraminidase of three A and three B Influenza Virus Strains, and the result of the comparison of biological and physical properties of human and animal origin (pig and duck) Virus Strains, belonging to the same subtype A(H1N1), are described. Finally, the advantages and risks for the use as therapeutic agents against Influenza of the Influenza Virus neuraminidase inhibitors Zanamivir, Oseltamivir and Peramivir are discussed.
Keywords: neuraminidase / sialidase; influenza virus; inhibitors
期刊介绍：
The Anales de la Real Academia Nacional de Farmacia� embraces all aspects of pharmaceutical sciences and is a quarterly journal that publishes basic and applied research on pharmaceutical sciences and related areas. It is a medium for reporting selected original and significant contributions to new pharmaceutical knowledge.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
