Effects of Red ginseng on neuroinflammation in neurodegenerative diseases

IF 6.8 2区医学 Q1 CHEMISTRY, MEDICINAL Journal of Ginseng Research Pub Date : 2024-01-01 DOI:10.1016/j.jgr.2023.08.003

Min Yeong Lee , Mikyung Kim

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Abstract

Red ginseng (RG) is widely used as a herbal medicine. As the human lifespan has increased, numerous diseases have developed, and RG has also been used to treat various diseases. Neurodegenerative diseases are major problems that modern people face through their lives. Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are featured by progressive nerve system damage. Recently, neuroinflammation has emerged as a degenerative factor and is an immune response in which cytokines with nerve cells that constitute the nervous system. RG, a natural herbal medicine with fewer side effects than chemically synthesized drugs, is currently in the spotlight. Therefore, we reviewed studies reporting the roles of RG in treating neuroinflammation and neurodegenerative diseases and found that RG might help alleviate neurodegenerative diseases by regulating neuroinflammation.

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红参对神经退行性疾病神经炎症的影响

红参（RG）作为一种草药被广泛使用。随着人类寿命的延长，出现了许多疾病，红参也被用来治疗各种疾病。神经退行性疾病是现代人一生面临的主要问题。包括阿尔茨海默病、帕金森病、亨廷顿病和肌萎缩性脊髓侧索硬化症在内的神经退行性疾病的特征是神经系统进行性损伤。最近，神经炎症已成为一种退化因素，它是一种细胞因子与构成神经系统的神经细胞相互作用的免疫反应。与化学合成药物相比，RG 是一种副作用较少的天然草药，目前正成为人们关注的焦点。因此，我们回顾了有关 RG 在治疗神经炎症和神经退行性疾病方面作用的研究报告，发现 RG 可能有助于通过调节神经炎症来缓解神经退行性疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Ginseng Research CHEMISTRY, MEDICINAL-INTEGRATIVE & COMPLEMENTARY MEDICINE

CiteScore

11.40

自引率

9.50%

发文量

111

审稿时长

6-12 weeks

期刊介绍： Journal of Ginseng Research (JGR) is an official, open access journal of the Korean Society of Ginseng and is the only international journal publishing scholarly reports on ginseng research in the world. The journal is a bimonthly peer-reviewed publication featuring high-quality studies related to basic, pre-clinical, and clinical researches on ginseng to reflect recent progresses in ginseng research. JGR publishes papers, either experimental or theoretical, that advance our understanding of ginseng science, including plant sciences, biology, chemistry, pharmacology, toxicology, pharmacokinetics, veterinary medicine, biochemistry, manufacture, and clinical study of ginseng since 1976. It also includes the new paradigm of integrative research, covering alternative medicinal approaches. Article types considered for publication include review articles, original research articles, and brief reports. JGR helps researchers to understand mechanisms for traditional efficacy of ginseng and to put their clinical evidence together. It provides balanced information on basic science and clinical applications to researchers, manufacturers, practitioners, teachers, scholars, and medical doctors.