Hyperuricosuria in the domestic dog (Canis lupus familiaris)

Abstract

Elevated plasma urate levels are associated with metabolic diseases such as hyperuricosuria. Long-term deposition of urea in the renal tubules can cause gout. Due to proper transport activity of GLUT9 (glucose transporter 9) protein, urate homeostasis in the body is maintained. GLUT9 is encoded by the SLC2A9 gene, which is expressed in the kidney and liver. The SLC2A9 c.616GG> T mutation results in a change in the amino acid sequences of the GLUT9 protein (p.Cys–188Phe, which in turn leads to hyperuricosuria. Molecular methods were used to identify the mutation in SLC2A9 gene. The occurrence of this mutation was found in many breeds of domestic dog (over 20), but the highest number of recessive homozygotes was recorded in the breeds: Dalmatian, Russian Black Terrier and English Bulldog.