Hypertrophic pulmonary osteoarthropathy, secretory diarrhea and pancoast syndrome in the setting of a large cell neuroendocrine carcinoma of the lung: A case report

Carley Mitchell , Leyla Bayat , Wadad Mneimneh , Debora Bruno
{"title":"Hypertrophic pulmonary osteoarthropathy, secretory diarrhea and pancoast syndrome in the setting of a large cell neuroendocrine carcinoma of the lung: A case report","authors":"Carley Mitchell ,&nbsp;Leyla Bayat ,&nbsp;Wadad Mneimneh ,&nbsp;Debora Bruno","doi":"10.1016/j.cpccr.2023.100241","DOIUrl":null,"url":null,"abstract":"<div><p>Large cell neuroendocrine carcinoma of the lung is a rare and aggressive pulmonary malignancy. Given its peripheral location, patients are frequently asymptomatic at the time of diagnosis or present with non-specific complaints. Moreover, its association with paraneoplastic syndromes or structural intrathoracic complications are highly atypical. Here, we report a case involving a 57-year-old female who presented with two simultaneous paraneoplastic syndromes, including hypertrophic pulmonary osteoarthropathy and secretory diarrhea, prior to the diagnosis of an early-stage large cell neuroendocrine carcinoma of the lung. Both syndromes showcased rapid symptomatic resolution following tumor resection. Upon disease recurrence, the patient developed a presentation consistent with Pancoast syndrome, with gradual improvement following the initiation of chemoradiotherapy. Individually, these conditions are rarely reported in association with large cell neuroendocrine carcinoma of the lung making their combination highly unusual. Furthermore, related symptoms were present both before and at the time of diagnosis, and upon disease recurrence. This highlights the importance of maintaining a high clinical suspicion for atypical manifestations of malignancy.</p></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":null,"pages":null},"PeriodicalIF":0.2000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current problems in cancer. Case reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S266662192300025X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Large cell neuroendocrine carcinoma of the lung is a rare and aggressive pulmonary malignancy. Given its peripheral location, patients are frequently asymptomatic at the time of diagnosis or present with non-specific complaints. Moreover, its association with paraneoplastic syndromes or structural intrathoracic complications are highly atypical. Here, we report a case involving a 57-year-old female who presented with two simultaneous paraneoplastic syndromes, including hypertrophic pulmonary osteoarthropathy and secretory diarrhea, prior to the diagnosis of an early-stage large cell neuroendocrine carcinoma of the lung. Both syndromes showcased rapid symptomatic resolution following tumor resection. Upon disease recurrence, the patient developed a presentation consistent with Pancoast syndrome, with gradual improvement following the initiation of chemoradiotherapy. Individually, these conditions are rarely reported in association with large cell neuroendocrine carcinoma of the lung making their combination highly unusual. Furthermore, related symptoms were present both before and at the time of diagnosis, and upon disease recurrence. This highlights the importance of maintaining a high clinical suspicion for atypical manifestations of malignancy.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
肺大细胞神经内分泌癌的增生性肺骨关节病、分泌性腹泻和Pancoast综合征1例报告
摘要肺大细胞神经内分泌癌是一种罕见的侵袭性肺恶性肿瘤。鉴于其外周位置,患者在诊断时通常无症状或表现为非特异性主诉。此外,它与副肿瘤综合征或结构性胸内并发症的关联是高度不典型的。在此,我们报告一例57岁女性患者,在诊断为早期肺大细胞神经内分泌癌之前,同时出现两种副肿瘤综合征,包括肥厚性肺骨关节病和分泌性腹泻。两种症状均显示肿瘤切除后症状迅速缓解。疾病复发后,患者出现与Pancoast综合征一致的表现,在开始放化疗后逐渐改善。单独来看,这些情况很少与肺大细胞神经内分泌癌相关,因此它们的合并非常不寻常。此外,在诊断前和诊断时以及疾病复发时均存在相关症状。这突出了对恶性肿瘤的非典型表现保持高度临床怀疑的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
0.40
自引率
0.00%
发文量
0
审稿时长
96 days
期刊最新文献
Prolonged survival in postoperative recurrent EGFR-L858R NSCLC: A 24-year case report Refractory chronic lymphocytic leukemia with concomitant extramedullary multiple myeloma with lymph node involvement Adeno-squamous carcinoma of bartholin gland: Challenges in diagnosis and management of a less known vulvar cancer – A case report Anaphylaxis from filgrastim prophylaxis within the same day of chemotherapy: A case report Refractory IgM AL amyloidosis with massive soft tissue tumors: Rescue with zanubrutinib. A case report
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1