Investigation of the Association between Periodontal Disease Indices and Risk of Acute Hematopoietic Cancer Development (Acute Myeloid and Acute Lymphoblastic Leukemia): A Case – Control Study

Abstract

The objective of the current research was to investigate the possible association between Periodontal Disease indices and risk of development Acute Hematopoietic Cancer (Acute Myeloid and Acute Lymphoblastic Leukemia) in a representative Greek adult sample. 174 individuals with Acute Myeloid and Acute Lymphoblastic Leukemia-cases and 174 matched healthy individuals- controls underwent an oral and dental clinical examination and completed a questionnaire. The periodontal condition for cases and controls included Probing Pocket Depth (PPD), Clinical Attachment Loss (CAL) and Gingival Index (GI). Chi-square test and logistic regression models were carried out to assess the possible association. The logistic regression model showed that CAL (p= 0.054) (OR= 2.467, 95% CI= 1.177-2.231), and GI (p= 0.043) (OR = 3.352, 95% CI= 1.285-4.745), were marginally significantly associated with an increased risk of developing Acute Hematopoietic Cancer.