The pattern of antibiotic sensitivity of gram-negative MDR bacteria in patients admitted to the ICU

Abstract

Due to the uncontrolled increase in the administration of antibiotics, the prevalence of multidrug-resistant organisms in patients admitted to intensive care units has also increased. Thus, this study aimed to investigate the pattern of sensitivity and compliance of treatment with the results of culture in gram-negative MDR bacteria in patients admitted to the intensive care unit of Shahid Sadoughi Hospital in Yazd. This cross-sectional study was performed over a period of one year on the results of culture of patients admitted to the intensive care unit of Shahid Sadoughi Hospital in Yazd (2020). The samples included blood, urine, wounds, bronchoalveolar lavage, shunt, and throat. All patient information and antibiotics prescribed were obtained using their records. Finally, the data was entered into SPSS (v. 26) and analyzed. In total, out of 298 patients for whom initial antibiotics were started experimentally, 226 cases had the culture results consistent with one of the antibiotics that were started initially. Among the antibiotics that were used more, clindamycin showed the least agreement with antibiotic sensitivity results. Among antibiotics, clindamycin had significantly the most compatibility in blood and urine and the least compatibility in wound. The present study showed a relatively good agreement in the initial experimental administration of antibiotics.