A practical one-pot three-component procedure for preparation of 3a,8a-dihydroxyindeno[1,2-d]imidazole derivatives in aqueous ethanol

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2018-06-04 DOI:10.1002/hc.21417

Azar Jamaledini, Mohammad Reza Mohammadizadeh

引用次数: 1

Abstract

The results of our investigations on the preparation of 3a,8a-dihydroxyindeno[1,2-d]imidazole derivatives via reaction of thiourea, ninhydrin, and alkyl/benzyl chlorides in aqueous ethanol and under convenient conditions is reported. On the other hand, when guanidinium chloride was used instead of thiourea, the reaction mixtures reached with unexpected products; 2,2-dialkoxy-1H-indene-1,3(2H)-diones.

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在乙醇水溶液中制备3a,8a-二羟基茚二酮[1,2-d]咪唑衍生物的一锅三组分工艺

报道了硫脲、茚三酮和烷基/苄基氯化物在乙醇水溶液中反应制备3a,8a-二羟基茚二酮[1,2-d]咪唑衍生物的研究结果。另一方面，当用氯化胍代替硫脲时，反应混合物会产生意想不到的产物;2 2-dialkoxy-1H-indene-1 3 (2 h) -diones。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.