{"title":"Construction of fluorescence system of felodipine–tetracyanovinyl–2,2′-bipyridine complex","authors":"Yan Lang, Yuanjun Zeng, Chunbin Zhang, Kuilin Lv","doi":"10.1515/gps-2022-8134","DOIUrl":null,"url":null,"abstract":"Abstract Felodipine (FEL)–tetracyanoethylene (TCNE)–2,2′-bipyridine (Bpy) complex was prepared with FEL, TCNE–Bpy and characterized by fluorescence, ultraviolet, and infrared. By exploring the concentration and dosage of Bpy, it was found that 1 mL 2 × 10−3 mol‧L−1 of Bpy had the best effect. The sequence of reagent addition was determined to be followed by FEL, then by TCNE, and then followed by Bpy. The concentration of FEL was 2.5 × 10−4 to 9.0 × 10−3 mol‧L−1, which had a good linear relationship with fluorescence intensity. The compound had good accuracy, precision, and specificity, and could be used for the determination of phelodipine content in FEL sustained-release tablets.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":" ","pages":""},"PeriodicalIF":3.8000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Green Processing and Synthesis","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1515/gps-2022-8134","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Abstract Felodipine (FEL)–tetracyanoethylene (TCNE)–2,2′-bipyridine (Bpy) complex was prepared with FEL, TCNE–Bpy and characterized by fluorescence, ultraviolet, and infrared. By exploring the concentration and dosage of Bpy, it was found that 1 mL 2 × 10−3 mol‧L−1 of Bpy had the best effect. The sequence of reagent addition was determined to be followed by FEL, then by TCNE, and then followed by Bpy. The concentration of FEL was 2.5 × 10−4 to 9.0 × 10−3 mol‧L−1, which had a good linear relationship with fluorescence intensity. The compound had good accuracy, precision, and specificity, and could be used for the determination of phelodipine content in FEL sustained-release tablets.
摘要以非洛地平（FEL）、四氰基乙烯（TCNE）-2，2′-联吡啶（Bpy）为原料，制备了非洛地平-四氰基烯（TCNE。通过对Bpy的浓度和剂量的探索，发现1 mL 2×10−3 mol·L−1的Bpy效果最好。试剂添加的顺序被确定为随后是FEL，然后是TCNE，然后是Bpy。FEL浓度为2.5×10−4～9.0×10−3 mol·L−1，与荧光强度呈良好的线性关系。该化合物具有良好的准确度、精密度和特异性，可用于非洛地平缓释片中非洛地平含量的测定。
期刊介绍：
Green Processing and Synthesis is a bimonthly, peer-reviewed journal that provides up-to-date research both on fundamental as well as applied aspects of innovative green process development and chemical synthesis, giving an appropriate share to industrial views. The contributions are cutting edge, high-impact, authoritative, and provide both pros and cons of potential technologies. Green Processing and Synthesis provides a platform for scientists and engineers, especially chemists and chemical engineers, but is also open for interdisciplinary research from other areas such as physics, materials science, or catalysis.
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