Holly polyphenols attenuate liver injury, suppression inflammation and oxidative stress in lipopolysaccharide-challenged weaned pigs

IF 1.7 3区农林科学 Q3 CHEMISTRY, APPLIED Food and Agricultural Immunology Pub Date : 2022-01-20 DOI:10.1080/09540105.2021.2022604

F. Huang, Y. Yang, L. Wang, H. Wang, P. Li, K. Xiao, X. Xu, J. Liu, Y. Liu, H. Zhu

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引用次数: 2

Abstract

ABSTRACT It has been proved that polyphenols have positive effects against inflammatory response and oxidative stress. We investigated whether dietary supplementation of the holly polyphenols (HP) might relieve a liver injury induced by lipopolysaccharide (LPS) in weaned pigs. Twenty-four weaned pigs were fed diets containing 0 or HP and saline or LPS challenge in 2×2 factorial arrangement of treatments. On d 17, pigs were intraperitoneally injected with an LPS or saline. Dietary HP supplementation reduced plasma AST and GGT activities and liver MDA levels, increased plasma ALB and TP and liver GSH concentrations, and ameliorated LPS-induced liver histopathological damage. HP supplementation reduced plasma and /or liver TNF-α, IL-6 and IL-1β levels, and liver mRNA expression of IL-6, TNF-α and COX2. Moreover, HP decreased the mRNA abundance of liver MyD88, TRAF6 and NOD1. These results suggest that HP supplementation attenuates liver injury induced by LPS in weaned pigs, and inhibits inflammatory response and oxidative stress.

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冬青多酚可减轻脂多糖应激断奶仔猪的肝损伤，抑制炎症和氧化应激

摘要多酚类物质已被证明对炎症反应和氧化应激具有积极作用。我们研究了日粮中添加冬青多酚（HP）是否可以减轻脂多糖（LPS）诱导的断奶仔猪肝损伤。24头断奶仔猪饲喂含0或HP的日粮和生理盐水或LPS，采用2×2因子处理。第17天，对猪腹膜内注射LPS或生理盐水。日粮中补充HP可降低血浆AST和GGT活性以及肝脏MDA水平，增加血浆ALB和TP以及肝脏GSH浓度，并改善LPS诱导的肝脏组织病理学损伤。HP补充降低了血浆和/或肝脏TNF-α、IL-6和IL-1β水平，以及肝脏IL-6、TNF-α和COX2的mRNA表达。此外，HP降低了肝脏MyD88、TRAF6和NOD1的mRNA丰度。这些结果表明，补充HP可以减轻LPS诱导的断奶仔猪肝损伤，并抑制炎症反应和氧化应激。

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来源期刊

Food and Agricultural Immunology 农林科学-毒理学

CiteScore

5.30

自引率

6.70%

发文量

审稿时长

2 months

期刊介绍： Food and Agricultural Immunology is an international open access journal publishing original immunological research with applications in food, agricultural, environmental and veterinary science. Submissions describing the use of immunological techniques and methods are particularly welcomed. The journal aims to expand our understanding of the interactions at the interface of food and immune systems including studies on: -Development of diagnostic systems – all types of ligand-based assays, e.g. antibody, aptamer -Application of ligand-based assays for the detection or identification of molecules of interest in food science, agricultural research, veterinary investigations and clinical systems relating to food allergy or sensitivity to agricultural chemicals -Effects of food on the immune system -Studies on allergy and allergic reactions -Investigations into food allergies -Development of allergen-free food systems -Development of novel assay formats -Applications of assay systems to the monitoring of food items in relation to safety and labelling -Food quality issues, e.g. speciation, adulteration and contamination -Comparisons between different analytical techniques The journal publishes research and review articles and is essential reading for food scientists, immunologists and all those concerned with the interaction between food and immune systems.