Effects of Diets Containing Unripe Plantain Diet on Brain Serotonin in Mice

Q4 Pharmacology, Toxicology and Pharmaceutics African Journal Biomedical Research Pub Date : 2017-09-30 DOI:10.4314/AJBR.V20I3

Idayat Titilayo Gbadamosi, Lekan Abdullahi Raji, A. Oyagbemi, T. O. Omobowale

{"title":"Effects of Diets Containing Unripe Plantain Diet on Brain Serotonin in Mice","authors":"Idayat Titilayo Gbadamosi, Lekan Abdullahi Raji, A. Oyagbemi, T. O. Omobowale","doi":"10.4314/AJBR.V20I3","DOIUrl":null,"url":null,"abstract":"Musa paradisiaca (Plantain) fruit has been shown to be useful for nutritional, medicinal and industrial purposes. It contains serotonin (5-HT) and its immediate precursor, 5-Hydroxytryptophan (5-HTP). Serotonin plays a fundamental role in integration of behaviour and many physiological functions including regulation of mood, anxiety, arousal, aggression, impulse control, and thinking abilities. In this study, the effect of plantain-containing mouse diet on brain serotonin mice was investigated in mice. Thirty adult Swiss mice were divided into three groups of ten each and fed normal rodent chow containing 0%, 50% and 100% unripe plantain. After thirty days, the brain levels of 5-HT and 5-HTP were measured using High Performance Liquid Chromatography (HPLC) technique. Results show that 5-HT level was significantly increased in the plantain-diet fed mice. Conversely, 5-HTP level was reduced in the 100% plantain fed mice when compared with the control. Keywords : Musa paradisiaca , Unripe plantain, serotonin, 5-Hydroxytryptophan","PeriodicalId":53615,"journal":{"name":"African Journal Biomedical Research","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2017-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4314/AJBR.V20I3","citationCount":"8","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"African Journal Biomedical Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4314/AJBR.V20I3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}

引用次数: 8

Abstract

Musa paradisiaca (Plantain) fruit has been shown to be useful for nutritional, medicinal and industrial purposes. It contains serotonin (5-HT) and its immediate precursor, 5-Hydroxytryptophan (5-HTP). Serotonin plays a fundamental role in integration of behaviour and many physiological functions including regulation of mood, anxiety, arousal, aggression, impulse control, and thinking abilities. In this study, the effect of plantain-containing mouse diet on brain serotonin mice was investigated in mice. Thirty adult Swiss mice were divided into three groups of ten each and fed normal rodent chow containing 0%, 50% and 100% unripe plantain. After thirty days, the brain levels of 5-HT and 5-HTP were measured using High Performance Liquid Chromatography (HPLC) technique. Results show that 5-HT level was significantly increased in the plantain-diet fed mice. Conversely, 5-HTP level was reduced in the 100% plantain fed mice when compared with the control. Keywords : Musa paradisiaca , Unripe plantain, serotonin, 5-Hydroxytryptophan

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

未成熟车前草日粮对小鼠脑血清素的影响

芭蕉果实已被证明可用于营养、药用和工业用途。它含有5-羟色胺（5-HT）及其直接前体5-羟色氨酸（5-HTP）。血清素在行为和许多生理功能的整合中发挥着重要作用，包括调节情绪、焦虑、唤醒、攻击性、冲动控制和思维能力。在本研究中，研究了含车前草的小鼠饮食对小鼠大脑血清素的影响。将30只成年瑞士小鼠分为三组，每组10只，喂食含有0%、50%和100%未成熟车前草的正常啮齿动物食物。30天后，用高效液相色谱（HPLC）技术测定脑内5-HT和5-HTP的水平。结果表明，在车前草日粮喂养的小鼠中，5-HT水平显著升高。相反，与对照组相比，100%车前草喂养的小鼠的5-HTP水平降低。关键词：芭蕉、未成熟芭蕉、5-羟色胺、5-羟色氨酸

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

African Journal Biomedical Research Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

0.50

自引率

0.00%

发文量