Explanation for different behavior of peripheral and central giant cell granuloma by CD44 and CD34 immunostaining

Q1 Medicine Journal of Investigative and Clinical Dentistry Pub Date : 2019-08-21 DOI:10.1111/jicd.12451

Massoumeh Zargaran, Fahimeh Baghaei, Abbas Moghimbeigi, Fereshteh Baghai

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引用次数: 1

Abstract

Aim

Despite their histopathological similarity, unlike peripheral giant cell granuloma (PGCG), central giant cell granuloma (CGCG) is an osteolytic lesion. Low motility of osteoclasts as bone-resorbing agents decreases osteolysis where CD44 plays a role. The lesion requires angiogenesis to grow which in turn may cause bone resorption. This study aims to compare CD44 and CD34 expression in PGCG and CGCG.

Methods

30 PGCG (group A) and 30 CGCG (group B) including non-aggressive (B1, N = 14) and aggressive (B2, N = 16) subgroups were evaluated for CD44 and CD34 expression through immunohistochemistry.

Results

CD44 staining intensity distribution (SID) score and CD44 labelling index (LI) in PGCG were significantly higher than those in CGCG, while microvessel density assessed by CD34 (MVD-CD34) was significantly higher in CGCG compared with PGCG. CD44-SID score and CD44-LI were higher for B1 whereas MVD-CD34 was higher for B2 (P < .05).

Conclusion

Different CD44 expression among the studied groups may be indicative of the different motility of osteoclastic giant cells which may influence bone resorption. Lower CD44 expression probably indicates higher osteoclastic giant cell motility in CGCG, which with its higher angiogenesis may explain the different clinical behavior of CGCG compared with that of PGCG.

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CD44和CD34免疫染色解释外周和中心巨细胞肉芽肿的不同行为。

目的尽管其组织病理学相似，但与外周巨细胞肉芽肿（PGCG）不同，中央巨细胞肉芽肿（CGCG）是一种溶骨性病变。破骨细胞作为骨吸收剂的低运动性降低了CD44发挥作用的骨溶解。病变需要血管生成才能生长，这反过来可能导致骨吸收。本研究旨在比较CD44和CD34在PGCG和CGCG中的表达。通过免疫组织化学方法评估30个PGCG（A组）和30个CGCG（B组）（包括非侵袭性（B1，N=14）和侵袭性（B2，N=16）亚组的CD44和CD34表达。结果PGCG的CD44染色强度分布（SID）评分和CD44标记指数（LI）显著高于CGCG，而CD34评估的微血管密度（MVD-CD34）显著高于PGCG。CD44-SID评分和CD44-LI在B1组中较高，而MVD-CD34在B2组中较高（P＜0.05）。结论研究组中CD44的不同表达可能表明破骨细胞巨细胞的不同运动性可能影响骨吸收。较低的CD44表达可能表明CGCG中破骨细胞巨细胞的运动性较高，其较高的血管生成可能解释了CGCG与PGCG不同的临床行为。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Investigative and Clinical Dentistry DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.90

自引率

0.00%

发文量

期刊介绍： Journal of Investigative and Clinical Dentistry (JICD) aims to publish quality, peer reviewed original research and topical reviews on all aspects of investigative and clinical dentistry and craniofacial research, including molecular studies related to oral health and disease. Although international in outlook, the Editor especially encourages papers from the Asia Pacific. The journal also aims to provide clinicians, scientists and students of dentistry with a knowledge transfer platform for rapid publication of reports through an international journal, which will be available free online until 2012. Its scope, therefore, is broad, inclusive and international, but with a particular focus on Asia Pacific. The Editor welcomes manuscripts in the following key thematic areas in oral and maxillofacial sciences: Community Dentistry and Oral Epidemiology, Conservative Dentistry, Dental Biomaterials, Dental Pedagogy, Endodontics and Traumatology, Implant Dentistry, Oral Biosciences, Oral and Maxillofacial Surgery, Oral Medicine, Oral Pathology and Oral Microbiology, Orthodontics, Oral Radiology, Oral Rehabilitation, Paedodontics, Periodontology and Periodontal Medicine.

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