Dong-Hwi Kim, Da-Yoon Kim, Jae-Hyeong Kim, Kyu-Beom Lim, Joong-Bok Lee, Seung-Yong Park, C. Song, Sang-Won Lee, I. Choi
{"title":"Experimental infection of a porcine kidney cell line with hepatitis A virus","authors":"Dong-Hwi Kim, Da-Yoon Kim, Jae-Hyeong Kim, Kyu-Beom Lim, Joong-Bok Lee, Seung-Yong Park, C. Song, Sang-Won Lee, I. Choi","doi":"10.14405/kjvr.20230019","DOIUrl":null,"url":null,"abstract":"The hepatitis A virus (HAV) induces severe acute liver injury and is adapted to human and monkey cell lines but not other cells. In this study, the HAV was inoculated into porcine kidney (PK-15) cells to determine its infectivity in porcine cells. The growth pattern of the HAV in PK-15 cells was compared with its growth pattern in fetal rhesus kidney (FRhK-4) cells. The growth of HAV was less efficient in PK-15 cells. In conclusion, HAV replication was verified in PK-15 cells for the first time. Further investigations will be needed to identify the HAV-restrictive mechanisms in PK-15 cells.","PeriodicalId":38891,"journal":{"name":"Korean Journal of Veterinary Research","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Korean Journal of Veterinary Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14405/kjvr.20230019","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Veterinary","Score":null,"Total":0}
引用次数: 0
Abstract
The hepatitis A virus (HAV) induces severe acute liver injury and is adapted to human and monkey cell lines but not other cells. In this study, the HAV was inoculated into porcine kidney (PK-15) cells to determine its infectivity in porcine cells. The growth pattern of the HAV in PK-15 cells was compared with its growth pattern in fetal rhesus kidney (FRhK-4) cells. The growth of HAV was less efficient in PK-15 cells. In conclusion, HAV replication was verified in PK-15 cells for the first time. Further investigations will be needed to identify the HAV-restrictive mechanisms in PK-15 cells.
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