Enhancing bone tissue regeneration with rGO-coated Si-Ca-P bioceramic scaffold

IF 2.7 4区材料科学 Q1 MATERIALS SCIENCE, CERAMICS Boletin de la Sociedad Espanola de Ceramica y Vidrio Pub Date : 2024-01-01 DOI:10.1016/j.bsecv.2023.05.002

Patricia Mazón , Jeevithan Elango , José Eduardo Maté-Sánchez de Val , Piedad N. De Aza

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Abstract

Ceramic-based bone graft substitutes have been extensively studied for bone tissue engineering, due to their biocompatibility and osteoconductivity. Additionally, several studies have shown how graphene and its derivatives, due to their unique properties, can strongly promote cell adhesion, by enhance cellular adherence, proliferation, and osteoblast differentiation, and how graphene-based materials can promote spontaneous osteoblastic differentiation. The aim of this study was the use of a calcium silicophosphate ceramic, previously prepared in our laboratory, that presents excellent in vitro bioactivity, optimizing its operation by rGO coating. After coating with rGO any significant differences were observed in diffraction peaks from starting calcium silicophosphate ceramic, and SEM analysis showed a rough and undulating surface that favored a high specific surface area for promoting cell adhesion, proliferation and differentiation of cells. It could be confirmed by in vitro cell cultured with ahMSCs, showing adhesion and growing for cells with interconnected filaments extending over the surface, covering it after 7 days.

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氧化石墨烯包被硅钙磷生物陶瓷支架促进骨组织再生

陶瓷基骨移植替代物因其生物相容性和骨传导性，已被广泛研究用于骨组织工程。此外，一些研究还表明，石墨烯及其衍生物因其独特的性质，可以通过增强细胞粘附、增殖和成骨细胞分化，以及石墨烯基材料如何促进成骨细胞自发分化，从而强烈促进细胞粘附。本研究的目的是使用我们实验室之前制备的硅磷酸钙陶瓷，这种陶瓷具有极佳的体外生物活性，通过涂覆 rGO 可以优化其操作。涂覆 rGO 后，与最初的硅磷酸钙陶瓷相比，衍射峰出现了明显差异，扫描电镜分析表明，陶瓷表面粗糙起伏，具有较高的比表面积，有利于促进细胞粘附、增殖和分化。这一点可通过体外培养 ahMSCs 得到证实，培养 7 天后，细胞粘附并生长，表面延伸出相互连接的细丝，并覆盖在表面。

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来源期刊

Boletin de la Sociedad Espanola de Ceramica y Vidrio 工程技术-材料科学：硅酸盐

CiteScore

5.50

自引率

2.90%

发文量

审稿时长

103 days

期刊介绍： The Journal of the Spanish Ceramic and Glass Society publishes scientific articles and communications describing original research and reviews relating to ceramic materials and glasses. The main interests are on novel generic science and technology establishing the relationships between synthesis, processing microstructure and properties of materials. Papers may deal with ceramics and glasses included in any of the conventional categories: structural, functional, traditional, composites and cultural heritage. The main objective of the Journal of the Spanish Ceramic and Glass Society is to sustain a high standard research quality by means of appropriate reviewing procedures.