The relationship between inflammatory markers and vitamin D levels with the severity of coronary artery disease in elderly patients

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL Bali Medical Journal Pub Date : 2022-12-01 DOI:10.15562/bmj.v11i3.3631
Charles Limantoro, Fandy Santoso, C. Suharti, Trilaksana Nugroho
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引用次数: 3

Abstract

Introduction: Coronary artery disease (CAD) is the accumulation of atherosclerotic plaques in the coronary arteries. CAD is the most common cause of death worldwide, and its prevalence continues to increase, especially in the elderly population. Atherosclerosis is a chronic inflammatory condition that involves various inflammatory markers, including tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). In the inflammatory process, vitamin D plays an essential role in developing atherosclerotic plaques affecting the severity of CAD. The elderly are susceptible to vitamin D deficiency and an increase in the inflammatory process related to the severity of CAD. Therefore, this study aims to prove the relationship between inflammatory markers and vitamin D levels with the severity of CAD in elderly patients. Methods: This study used a cross-sectional design in stable CAD patients aged 60 - 75 years who had passed through coronary arteriography. The severity was assessed from the angiography results using the Synergy between PCI with Taxus and Cardiac Surgery (SYNTAX) score, which 3 cardiovascular consultants evaluated and the average outcome was calculated. TNF-α, IL-6, and vitamin D were taken during angiography and examined using high sensitivity enzyme-linked immunoabsorbent assay (ELISA). The correlation test was analyzed using Spearman's Rank correlation test. Results: A total of 38 subjects were included in this study, where 30 (78.9%) patients were male. The mean age of the patients was 64.79 years, and the prevalence of vitamin D deficiency was 57.9%. There was a moderately significant positive correlation between markers of inflammation TNF-α (r=0.499, p=0.001) and IL-6 (r=0.518, p=0.001) and the SYNTAX score. A weak negative correlation was also discovered between vitamin D and the SYNTAX score (r=-0.335, p=0.040). Conclusion: The levels of inflammatory markers (TNF-α and IL-6) and vitamin D correlated with the severity of CAD in elderly patients.
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老年冠心病患者炎症标志物和维生素D水平与病情严重程度的关系
引言:冠状动脉疾病(CAD)是冠状动脉中动脉粥样硬化斑块的积聚。CAD是全世界最常见的死亡原因,其流行率持续上升,尤其是在老年人群中。动脉粥样硬化是一种慢性炎症性疾病,涉及各种炎症标志物,包括肿瘤坏死因子α(TNF-α)和白细胞介素-6(IL-6)。在炎症过程中,维生素D在动脉粥样硬化斑块的形成中起着重要作用,影响CAD的严重程度。老年人易患维生素D缺乏症和与CAD严重程度相关的炎症过程增加。因此,本研究旨在证明炎症标志物和维生素D水平与老年患者CAD严重程度之间的关系。方法:本研究采用横断面设计对60-75岁的稳定型CAD患者进行冠状动脉造影。根据血管造影结果,使用经皮冠状动脉介入治疗与Taxus和心脏外科手术之间的协同作用(SYNTAX)评分评估严重程度,3名心血管顾问对此进行了评估,并计算了平均结果。在血管造影术期间采集TNF-α、IL-6和维生素D,并使用高灵敏度酶联免疫吸附法(ELISA)进行检测。相关检验采用Spearman秩相关检验进行分析。结果:本研究共纳入38名受试者,其中30名(78.9%)患者为男性。患者的平均年龄为64.79岁,维生素D缺乏症的患病率为57.9%。炎症标志物TNF-α(r=0.499,p=0.001)和IL-6(r=0.518,p=0.000)与SYNTAX评分呈中度显著正相关。维生素D与SYNTAX评分呈弱负相关(r=-0.335,p=0.040)。结论:老年患者炎症标志物(TNF-α和IL-6)和维生素D水平与CAD的严重程度相关。
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来源期刊
Bali Medical Journal
Bali Medical Journal MEDICINE, GENERAL & INTERNAL-
自引率
50.00%
发文量
8
审稿时长
3 weeks
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