Production of actinium-225 from a (n,p) reaction: Feasibility and pre-design studies

IF 0.7 4区 物理与天体物理 Q4 CHEMISTRY, INORGANIC & NUCLEAR Nukleonika Pub Date : 2021-06-01 DOI:10.2478/nuka-2021-0008
F. Abolaban, E. Banoqitah, Eslam M. Taha, A. Alhawsawi, F. Djouider, A. Nisbet
{"title":"Production of actinium-225 from a (n,p) reaction: Feasibility and pre-design studies","authors":"F. Abolaban, E. Banoqitah, Eslam M. Taha, A. Alhawsawi, F. Djouider, A. Nisbet","doi":"10.2478/nuka-2021-0008","DOIUrl":null,"url":null,"abstract":"Abstract Actinium-225 is used in nuclear medicine for the treatment of malignant tumours. It can be applied to produce Bi-213 in a reusable generator or can be used alone as an agent for radiation therapy, in particular for targeted alpha therapy. However, the availability of Ac-225 for worldwide use, particularly in low- and middle-income countries, is limited. We present a feasibility study employing GATE, an open-source Monte Carlo simulation toolkit, on the production of Ac-225 from a neutron generator. This work suggests that a design consisting of three concentric cylinders, the innermost a Cf-252 neutron source, the middle nickel cylinder acting as a proton-producing target and the outer cylinder a RaCl2 target may provide a feasible design outline for an Ac-225 generator.","PeriodicalId":19467,"journal":{"name":"Nukleonika","volume":"66 1","pages":"61 - 67"},"PeriodicalIF":0.7000,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nukleonika","FirstCategoryId":"101","ListUrlMain":"https://doi.org/10.2478/nuka-2021-0008","RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
引用次数: 0

Abstract

Abstract Actinium-225 is used in nuclear medicine for the treatment of malignant tumours. It can be applied to produce Bi-213 in a reusable generator or can be used alone as an agent for radiation therapy, in particular for targeted alpha therapy. However, the availability of Ac-225 for worldwide use, particularly in low- and middle-income countries, is limited. We present a feasibility study employing GATE, an open-source Monte Carlo simulation toolkit, on the production of Ac-225 from a neutron generator. This work suggests that a design consisting of three concentric cylinders, the innermost a Cf-252 neutron source, the middle nickel cylinder acting as a proton-producing target and the outer cylinder a RaCl2 target may provide a feasible design outline for an Ac-225 generator.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
从(n,p)反应生产锕-225:可行性和预设计研究
摘要锕-225在核医学中用于治疗恶性肿瘤。它可以用于在可重复使用的发生器中生产Bi-213,或者可以单独用作放射治疗,特别是靶向α治疗的试剂。然而,Ac-225在全球范围内的可用性,特别是在中低收入国家,是有限的。我们提出了一项可行性研究,采用开源蒙特卡罗模拟工具包GATE,从中子发生器生产Ac-225。这项工作表明,由三个同心圆柱体组成的设计,最内侧的是Cf-252中子源,中间的镍圆柱体用作质子产生靶,外侧的圆柱体是RaCl2靶,可以为Ac-225发生器提供可行的设计大纲。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Nukleonika
Nukleonika 物理-无机化学与核化学
CiteScore
2.00
自引率
0.00%
发文量
5
审稿时长
4-8 weeks
期刊介绍: "Nukleonika" is an international peer-reviewed, scientific journal publishing original top quality papers on fundamental, experimental, applied and theoretical aspects of nuclear sciences. The fields of research include: radiochemistry, radiation measurements, application of radionuclides in various branches of science and technology, chemistry of f-block elements, radiation chemistry, radiation physics, activation analysis, nuclear medicine, radiobiology, radiation safety, nuclear industrial electronics, environmental protection, radioactive wastes, nuclear technologies in material and process engineering, radioisotope diagnostic methods of engineering objects, nuclear physics, nuclear reactors and nuclear power, reactor physics, nuclear safety, fuel cycle, reactor calculations, nuclear chemical engineering, nuclear fusion, plasma physics etc.
期刊最新文献
Numerical studies of plasma edge in W7-X with 3D FINDIF code Photomultiplier tube signal conditioning for high-temperature applications Computer-simulated degradation of CF3Cl, CF2Cl2, and CFCl3 under electron beam irradiation Mechanical design of the gamma blockers for the high-energy beam transport region of the European Spallation Source Radon exposure in kindergartens in one Bulgarian district
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1