Pharmacological Properties of Genista sagittalis L. (Fabaceae) Grown in Turkey

IF 1 Q4 CHEMISTRY, MULTIDISCIPLINARY Indonesian Journal of Chemistry Pub Date : 2023-05-29 DOI:10.22146/ijc.79477

Pelin Şenel, Bleda Can Sadikogullari, E. Çepni Yüzbaşıoğlu, Gulnur Mertoglu Elmas, D. Oral, A. Gölcü, Ayşe Daut Özdemir

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Abstract

The genus Genista L. (Family: Fabaceae) is a plant having several traditional uses for treating common ailments such as diabetes, ulcer, and respiratory diseases. In this current study, the composition of essential oil and the biological activities of Genista sagittalis L. (Fabaceae) from Kocaeli: Yuvacık Dam Basin have been studied. A total of fourteen components were identified in the essential oil. The identified compounds belonged to straight-chain alkane, aromatic ether, and terpenoid derivatives. The antibacterial activity analyses demonstrated that G. sagittalis flower extract only had low activity against P. mirabilis and P. aeruginosa with MICs 1 to 2 mg/mL, as the peduncle extract showed strong anti-QS activity at 1.3 mg/mL. To the best of our knowledge, the current work is the first to report the antimicrobial and anti-quorum sensing activity of G. sagittalis growing in Turkey. Double-stranded DNA binding affinity investigations of the flower and peduncle ethanol extracts indicate that there are interactions with double-stranded DNA and related binding constants (Kb) were found as 1.97×103±0.37 and 3.68×102±0.44 for the flower and peduncle extract, respectively.

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产自土耳其的矢车菊(豆科)的药理特性

Genista L.属（科：豆科）是一种植物，有几种传统用途，用于治疗常见疾病，如糖尿病、溃疡和呼吸系统疾病。在本研究中，研究了来自科卡埃利：尤瓦克大坝盆地的箭花科植物Genista sagittalis L.的精油成分和生物活性。精油中共鉴定出14种成分。鉴定的化合物属于直链烷烃、芳香醚和萜类衍生物。抗菌活性分析表明，箭花提取物对奇异紫外菌和铜绿假单胞菌的MIC为1至2 mg/mL时活性较低，而茎梗提取物在1.3 mg/mL时表现出较强的抗QS活性。据我们所知，目前的工作是第一次报道生长在土耳其的箭状芽孢杆菌的抗菌和抗群体感应活性。花和花序梗乙醇提取物的双链DNA结合亲和力研究表明，花和花序蒂乙醇提取物与双链DNA存在相互作用，相关结合常数（Kb）分别为1.97×103±0.37和3.68×102±0.44。

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来源期刊

Indonesian Journal of Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

2.30

自引率

11.10%

发文量

106

审稿时长

15 weeks

期刊介绍： Indonesian Journal of Chemistry is a peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry, including educational chemistry, applied chemistry, and chemical engineering.