Chhaya. M Suryawanshi, Harsha Narkhede, Dipanjali Mahanta
{"title":"Clinical outcomes of COVID-19 patients after sequential oxygen therapy in Tertiary Medical College","authors":"Chhaya. M Suryawanshi, Harsha Narkhede, Dipanjali Mahanta","doi":"10.4103/bjoa.bjoa_179_21","DOIUrl":null,"url":null,"abstract":"Background: Acute respiratory failure is the main manifestation in patients with severe coronavirus disease (COVID-19), being hospitalized in an intensive care unit, and may even require invasive mechanical ventilation, which is associated with high mortality. The use of high-flow nasal oxygen (HFNO) for severe hypoxemic respiratory failure cases was limited in hospital setups. Its benefit to patients, compliance, complications, as well as comparison with non-invasive ventilation (NIV) mask were not studied. Patients and Methods: We included consecutive patients with COVID-19 acute respiratory failure who were categorized into three groups depending on admission oxygen saturation and respiratory rate for non-rebreather bag-mask (NRBM), HFNO, and NIV. All patients were observed for 2 weeks and defined parameters were noted. The mean and standard deviation were compared between the groups by using the ANOVA test; P-value <0.05 was considered as statistically significant. Results: The comparison of mean escalation of oxygen requirement on the 5th day showed a significant result (94.27 ± 1.7 vs. 92.16 ± 4.05 vs. 90.73 ± 2.49, respectively, P = 0.001). Similar findings were also found on the 10th day and 15th day of treatment. The NIV group showed a significant lack of compliance to oxygen therapy (P < 0.001) and also a significant incidence of complications (P < 0.001). Conclusion: NIV showed a significant amount of escalation in oxygen requirement, reduced therapy compliance, and associated complications in comparison to the NRBM and HFNO in COVID-19 settings.","PeriodicalId":8691,"journal":{"name":"Bali Journal of Anesthesiology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bali Journal of Anesthesiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/bjoa.bjoa_179_21","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Nursing","Score":null,"Total":0}
引用次数: 1
Abstract
Background: Acute respiratory failure is the main manifestation in patients with severe coronavirus disease (COVID-19), being hospitalized in an intensive care unit, and may even require invasive mechanical ventilation, which is associated with high mortality. The use of high-flow nasal oxygen (HFNO) for severe hypoxemic respiratory failure cases was limited in hospital setups. Its benefit to patients, compliance, complications, as well as comparison with non-invasive ventilation (NIV) mask were not studied. Patients and Methods: We included consecutive patients with COVID-19 acute respiratory failure who were categorized into three groups depending on admission oxygen saturation and respiratory rate for non-rebreather bag-mask (NRBM), HFNO, and NIV. All patients were observed for 2 weeks and defined parameters were noted. The mean and standard deviation were compared between the groups by using the ANOVA test; P-value <0.05 was considered as statistically significant. Results: The comparison of mean escalation of oxygen requirement on the 5th day showed a significant result (94.27 ± 1.7 vs. 92.16 ± 4.05 vs. 90.73 ± 2.49, respectively, P = 0.001). Similar findings were also found on the 10th day and 15th day of treatment. The NIV group showed a significant lack of compliance to oxygen therapy (P < 0.001) and also a significant incidence of complications (P < 0.001). Conclusion: NIV showed a significant amount of escalation in oxygen requirement, reduced therapy compliance, and associated complications in comparison to the NRBM and HFNO in COVID-19 settings.