Assessment of Lipid Peroxidation and Antioxidant Status in a Sample of Prostate Cancer Patients in Bangladesh

Abstract

Background: Prostate cancer (PCa) is the second leading cause of cancer-related mortality in men. Oxidative stress has long been implicated in cancer development and progression. Objective: To evaluate the lipid peroxidation and antioxidant status in a sample of prostate cancer patients in Bangladesh. Methods: This case-control study included 207 histopathologically confirmed cases of prostate cancer and 200 age-matched healthy controls. After taking informed written consent, preset questioners were filled up, and about 5 ml of venous blood were collected with all aseptic precaution from each study subject for estimation of serum PSA, MDA, GST, SOD and erythrocyte reduced glutathione (GSH). All data were plotted in SPSS version 23, and different statistical analyses were done. Results: In this study, the mean age of cases was 67.27±8.28 years, and among control, it was 62.17±6.77 years. Oxidative stress marker malondialdehyde was found significantly increased in prostate cancer patients than control. On the other hand, antioxidant erythrocyte reduced glutathione (GSH), and superoxide dismutase (SOD) were significantly reduced, and glutathione S transferase (GST) activity was significantly increased in prostate cancer patients, compared to control group. Conclusion: This study revealed that overall oxidative stress was increased, and antioxidant levels were impaired in prostate cancer patients, which might play an important role in carcinogenesis. So, screening of oxidative stress and antioxidant status in the elderly male in a regular interval is recommended for early detection and proper management to prevent the aetiopathogenesis of prostate cancer. Bangladesh Med Res Counc Bull 2022; 48(1): 21-26