The efficacy of N-acetylcysteine in improving liver function: A systematic review and meta-analysis of controlled clinical trials

IF 2.4 Q3 NUTRITION & DIETETICS PharmaNutrition Pub Date : 2023-06-01 DOI:10.1016/j.phanu.2023.100343
Mahlagha Nikbaf-Shandiz , Shaghayegh Adeli , Amir Hossein Faghfouri , Fateme Khademi , Parsa Jamilian , Meysam Zarezadeh , Mehrangiz Ebrahimi-Mamaghani
{"title":"The efficacy of N-acetylcysteine in improving liver function: A systematic review and meta-analysis of controlled clinical trials","authors":"Mahlagha Nikbaf-Shandiz ,&nbsp;Shaghayegh Adeli ,&nbsp;Amir Hossein Faghfouri ,&nbsp;Fateme Khademi ,&nbsp;Parsa Jamilian ,&nbsp;Meysam Zarezadeh ,&nbsp;Mehrangiz Ebrahimi-Mamaghani","doi":"10.1016/j.phanu.2023.100343","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>N-acetylcysteine (NAC) could improve liver function through its antioxidant and anti-inflammatory activities. We conducted a systematic review<span> and meta-analysis of randomized clinical trials to examine whether NAC administration could lead to changes in liver function.</span></p></div><div><h3>Methods</h3><p>The search was done using appropriate keywords in PubMed-Medline, SCOPUS, Embase databases and Google Scholar up to July 2022. Random-effects model was employed to obtain the pooled estimate. Additional analyses including subgroup and sensitivity analyses were carried out.</p></div><div><h3>Results</h3><p><span><span>Eight eligible studies were identified. The results indicated no significant effect of NAC on aspartate aminotransferase (AST), alanine aminotransferase (ALT), </span>alkaline phosphatase (ALP), [(SMD= −0.03 pg/ml; 95% CI: −0.53, 0.47; P = 0.917, I</span><sup>2</sup> = 71.3%, P = 0.004), (SMD= −0.22 pg/ml; 95% CI: −0.63, 0.19; P = 0.288, I<sup>2</sup> = 56.9%, P = 0.040), (SMD= −0.22 pg/ml; 95% CI: −0.67, 0.23; P = 0.343, I<sup>2</sup><span> = 52.6%, P = 0.097), respectively], however, it significantly increased albumin (ALB) and decreased bilirubin levels [(SMD= 1.05 pg/ml; 95% CI: 0.41, 1.69; P &lt; 0.001, I</span><sup>2</sup> = 87.3%, P &lt; 0.001) and (SMD= −0.34 pg/ml; 95% CI: −0.53, −0.14; P &lt; 0.001, I<sup>2</sup> = 0.0%, P = 0.447) respectively].</p></div><div><h3>Conclusion</h3><p>Although NAC might have favorable effect on ALB and bilirubin levels, larger trials assessing liver function as primary outcome are required.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":2.4000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"PharmaNutrition","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2213434423000154","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 0

Abstract

Background

N-acetylcysteine (NAC) could improve liver function through its antioxidant and anti-inflammatory activities. We conducted a systematic review and meta-analysis of randomized clinical trials to examine whether NAC administration could lead to changes in liver function.

Methods

The search was done using appropriate keywords in PubMed-Medline, SCOPUS, Embase databases and Google Scholar up to July 2022. Random-effects model was employed to obtain the pooled estimate. Additional analyses including subgroup and sensitivity analyses were carried out.

Results

Eight eligible studies were identified. The results indicated no significant effect of NAC on aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), [(SMD= −0.03 pg/ml; 95% CI: −0.53, 0.47; P = 0.917, I2 = 71.3%, P = 0.004), (SMD= −0.22 pg/ml; 95% CI: −0.63, 0.19; P = 0.288, I2 = 56.9%, P = 0.040), (SMD= −0.22 pg/ml; 95% CI: −0.67, 0.23; P = 0.343, I2 = 52.6%, P = 0.097), respectively], however, it significantly increased albumin (ALB) and decreased bilirubin levels [(SMD= 1.05 pg/ml; 95% CI: 0.41, 1.69; P < 0.001, I2 = 87.3%, P < 0.001) and (SMD= −0.34 pg/ml; 95% CI: −0.53, −0.14; P < 0.001, I2 = 0.0%, P = 0.447) respectively].

Conclusion

Although NAC might have favorable effect on ALB and bilirubin levels, larger trials assessing liver function as primary outcome are required.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
N-乙酰半胱氨酸改善肝功能的疗效:对照临床试验的系统综述和荟萃分析
背景N-乙酰半胱氨酸(NAC)具有抗氧化和抗炎作用,可改善肝功能。我们对随机临床试验进行了系统回顾和荟萃分析,以检查NAC给药是否会导致肝功能变化。方法截至2022年7月,在PubMed Medline、SCOPUS、Embase数据库和Google Scholar中使用适当的关键词进行搜索。采用随机效应模型来获得合并估计。进行了其他分析,包括亚组和敏感性分析。结果确定了8项符合条件的研究。结果表明,NAC对天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)、碱性磷酸酶(ALP)、,[(SMD=−0.03 pg/ml;95%置信区间:−0.53,0.47;P=0.917,I2=71.3%,P=0.004),(SMD=−0.22 pg/ml;95%CI:−0.63,0.19;P=0.288,I2=56.9%,P=0.040),它显著增加了白蛋白(ALB)并降低了胆红素水平[(SMD=1.05 pg/ml;95%CI:0.41,1.69;P<;0.001,I2=87.3%,P<;001)和(SMD=-0.34 pg/ml;95%CI:−0.53,−0.14;P<,0.001,I2=0.0%,P=0.447)]。结论尽管NAC可能对ALB和胆红素水平有良好影响,但仍需要更大规模的试验来评估肝功能作为主要结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
PharmaNutrition
PharmaNutrition Agricultural and Biological Sciences-Food Science
CiteScore
5.70
自引率
3.10%
发文量
33
审稿时长
12 days
期刊最新文献
Advancements in psoriasis management: Integrating nutrient supplement with gut-brain-skin connection Can L-Methionine and S-Adenosyl-L-Methionine Effectively Mitigate Scopolamine-Induced Cognitive and Motor Deficits in Mice? Melatonin supplementation in preclinical colitis models: A systematic review and dose-response meta-analysis on inflammation, oxidative stress, and colon repair Efficacy and safety of liraglutide on C-reactive protein (CRP) in adults with type 2 diabetes: A GRADE-assessed systematic review and dose-response meta-analysis of controlled trials Editorial Board
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1