Haemodynamic and Haemato-Biochemical Changes with Ketamine, Propofol and Ketofol as Constant Rate Infusion Anesthesia for Elective Ovariectomy in Dogs

Abstract

Background: Combination of glycopyrrolate, butorphanol, xylazine as premedication and induction with propofol and maintenance with ketamine, propofol and propofol mixtures (Ketofol 1:1) as constant rate infusion (CRI) would have the ability to maintain better hemodynamic and reduce the dose of general anesthesia for maintenance. This technique once gets standardized; it may transfer to field veterinarians for elective ovariectomy under a routine animal birth control programme (ABC) for safe handling of canines. Therefore, the present study was designed to evaluate haemodynamic and haemato-biochemical changes with Ketamine, Propofol and Ketofol as CRI anesthesia in dogs. Methods: The study was conducted on 18 female dogs during 2019-2021 and these animals were randomly divided into three experimental groups, each group (I, II and III) containing six animals. All animals were pre-medicated with glycopyrrolate @ 0.01 mg/kg b.wt I/M followed by inj. butorphanol 0.2 mg/kg b.wt and xylazine 1mg/kg b.wt I/M after 5 minutes by using different syringes. After 10 minutes of xylazine, animals were induced (till effect) with propofol and immediately just after induction animals were maintained with constant rate infusion of ketamine, propofol and ketofol 1:1 along with normal saline @ 10 ml/kg/hr. Result: Cardiovascular parameters showed that the value of systolic arterial pressure increased significantly (P less than 0.05) after pre-medication in all three groups in comparisons to respective base values. Value of diastolic arterial pressure increased significantly (P less than 0.05) after pre-medication in groups I and II, whereas non-significantly (p greater than 0.05) in group III in comparisons to respective base values. Hemoglobin and PCV values decreased non-significantly after pre-medication and remained non-significantly lower at various intervals in comparison to respective base values during observation periods except at recovery in group II. Changes in TLC did not show a definite pattern and values of TEC in all groups changed non-significantly (p greater than 0.05) at various time intervals in comparison to respective base values during the observation period.