Developments of microfluidics for orthopedic applications: A review

Q1 Engineering Smart Materials in Medicine Pub Date : 2023-01-01 DOI:10.1016/j.smaim.2022.07.001
Miao Sun , Jiaxing Gong , Wushi Cui , Congsun Li , Mengfei Yu , Hua Ye , Zhanfeng Cui , Jing Chen , Yong He , An Liu , Huiming Wang
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引用次数: 4

Abstract

With the development of modern medicine, the research methods of occurrence, development and treatment of orthopedic diseases are developing rapidly. The microenvironment provided by traditional orthopedic research methods differ considerably from the human body, resulting in poor or inconsistent conclusions in previous studies. Microfluidic technology has shown its advantages in the field of orthopedic research, especially in providing bionic mechanical stimulation environment. The microfluidic device can simulate the complex internal environment through the fine and complex structure and perfusion control system, and provide a stable, controllable and efficient culture system. Moreover, it can serve as a manufacturing device, which can produce bone grafts or bone like organs for tissue engineering with bionic structure. It can also simultaneously act as a detection device, which can realize high-throughput detection of small samples at low cost. In addition, we can establish in vitro physiological or pathological models on microfluidic systems to assist in the diagnosis and treatment of orthopedic diseases. This paper reviews the medical application of microfluidic devices in orthopedics.

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微流体在骨科应用中的发展综述
随着现代医学的发展,骨科疾病的发生、发展和治疗的研究方法也在迅速发展。传统骨科研究方法提供的微环境与人体存在较大差异,导致以往研究结论不佳或不一致。微流控技术在骨科研究领域,特别是在提供仿生机械刺激环境方面已显示出其优势。微流控装置可以通过精细复杂的结构和灌注控制系统模拟复杂的内部环境,提供稳定、可控、高效的培养系统。此外,它还可以作为一种制造装置,用于生产具有仿生结构的组织工程的骨移植物或骨样器官。也可同时作为检测装置,以低成本实现小样本的高通量检测。此外,我们还可以在体外建立微流控系统的生理或病理模型,以辅助骨科疾病的诊断和治疗。本文综述了微流控装置在骨科中的应用。
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来源期刊
Smart Materials in Medicine
Smart Materials in Medicine Engineering-Biomedical Engineering
CiteScore
14.00
自引率
0.00%
发文量
41
审稿时长
48 days
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