Challenges in simulating the biochemical environment of the infant stomach to assess the gastric digestion of infant formulae

IF 8.9 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Current Opinion in Food Science Pub Date : 2023-04-01 DOI:10.1016/j.cofs.2022.100984
Xin Wang , Debashree Roy , Alejandra Acevedo-Fani , Aiqian Ye , Shikha Pundir , Harjinder Singh
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引用次数: 2

Abstract

In infants, gastric digestion is a crucial step for the digestion and absorption of nutrients from infant formula, human milk, or any other milk substitutes. Critical understanding of the dynamics and biochemical conditions of the infant stomach is essential to improving the accuracy and reliability of in vitro models and guide the development of infant formulae that match the functional performance of human milk. This review discusses the current knowledge about infant gastric digestion gained from in vitro, in vivo, and human studies and learning from the digestion behavior of infant formulae. In particular, the current challenges when mimicking the gastric digestion processes in healthy infants are highlighted.

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模拟婴儿胃的生化环境以评估婴儿配方食品的胃消化的挑战
在婴儿中,胃消化是消化和吸收婴儿配方奶粉、人乳或任何其他代用品中营养物质的关键步骤。对婴儿胃的动力学和生化条件的批判性理解对于提高体外模型的准确性和可靠性以及指导婴儿配方奶粉的开发与人乳的功能性能相匹配至关重要。本文综述了目前从体外、体内和人体研究中获得的关于婴儿胃消化的知识,以及从婴儿配方奶粉的消化行为中获得的知识。特别是,当前的挑战,当模仿健康婴儿的胃消化过程被强调。
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来源期刊
Current Opinion in Food Science
Current Opinion in Food Science Agricultural and Biological Sciences-Food Science
CiteScore
18.40
自引率
4.00%
发文量
157
审稿时长
92 days
期刊介绍: Current Opinion in Food Science specifically provides expert views on current advances in food science in a clear and readable format. It also evaluates the most noteworthy papers from original publications, annotated by experts. Key Features: Expert Views on Current Advances: Clear and readable insights from experts in the field regarding current advances in food science. Evaluation of Noteworthy Papers: Annotated evaluations of the most interesting papers from the extensive array of original publications. Themed Sections: The subject of food science is divided into themed sections, each reviewed once a year.
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