Nanocarrier from water extract solution of Auricularia auricula for zinc delivery

IF 4.6 Q1 CHEMISTRY, APPLIED Food Hydrocolloids for Health Pub Date : 2022-12-01 DOI:10.1016/j.fhfh.2022.100070
Xiaoting Yu , Yannan Chen , Shanghua Xing , Deyang Yu , Mingqian Tan
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Abstract

Food-borne nanoparticles (FNs) may have potential for microelement delivery due to their good biocompatibility and healthy benefits. In this paper, hydrophilic FNs with ultra-small size of 1.7 nm were prepared from the water extract solution of Auricularia auricula by hydrothermal method. The structural characterization showed that Zn(II)-FNs were formed after the interaction of abundant functional groups like amino, hydroxyl, and carboxyl functional groups on the surface of FNs with Zn2+. The Zn(II)-FNs showed better cell compatibility than ZnSO4 and zinc gluconate with no visible cytotoxicity at concentrations up to 75 μg/mL for the normal rat kidney cells. Less than 5% hemolysis rate was found when the concentration of Zn(II)-FNs was 5 mg/mL after incubation for 3h. The biodistribution experiments indicated that Zn(II)-FNs had no obvious toxic effect after being orally administrated at a dose of 500 mg/kg mouse body weight, and Zn(II)-FNs were present in the stomach, intestine, lung, liver, and kidney. Our data indicated that FNs collected from Auricularia auricula water extract solution might act as a safe and effective nanocarrier for Zn(II).

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黑木耳水提液制备纳米锌载体
由于其良好的生物相容性和健康益处,食源性纳米颗粒(FNs)可能具有微量元素递送的潜力。本文以黑木耳水提液为原料,采用水热法制备了尺寸为1.7 nm的超小亲水性纳米颗粒。结构表征表明,Zn(II)-FNs是由FNs表面丰富的氨基、羟基、羧基官能团与Zn2+相互作用形成的。在75 μg/mL浓度下,Zn(II)-FNs对正常大鼠肾细胞的细胞相容性优于ZnSO4和葡萄糖酸锌,且无明显细胞毒性。孵育3h后,当Zn(II)-FNs浓度为5 mg/mL时,溶血率小于5%。生物分布实验表明,以500 mg/kg小鼠体重给药后,Zn(II)-FNs无明显毒性作用,且在胃、肠、肺、肝、肾中均存在Zn(II)-FNs。结果表明,木耳水提液中提取的FNs可作为锌(II)安全有效的纳米载体。
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审稿时长
61 days
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