A. Popa-Wagner, M. Popescu-Drigă, Leonard-Radu Pinosanu, Monica Grigore, Flavia Semida Ghinea, B. Căpitănescu, D. Hermann
{"title":"A clinically relevant model of stroke using aged rats","authors":"A. Popa-Wagner, M. Popescu-Drigă, Leonard-Radu Pinosanu, Monica Grigore, Flavia Semida Ghinea, B. Căpitănescu, D. Hermann","doi":"10.24238/13221-12-1-198","DOIUrl":null,"url":null,"abstract":"Comorbidities like diabetes, arterial hypertension, or comorbidity factors such as \nhypercholesterolemia is common in elderly persons and are associated with higher \nrisk of stroke. Since stroke afflicts mostly the elderly comorbid patients, it is highly desirable to test the efficacy of cell therapies in an appropriate animal stroke model. Animal models of stroke often ignore age and comorbidities frequently associated with aging, and this could be one of the explanations for unsuccessful bench-to-bedside translation of neuroprotective strategies. In order to mimic more closely the clinical condition, we have established a model of ischemic stroke in aged rats. Using this model, we showed that post-stroke angiogenesis is not impaired in the lesioned, aged brain and conclude that stroke in aged rodent models in reliable and more closely related to the human condition.","PeriodicalId":23948,"journal":{"name":"Vascular Cell","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vascular Cell","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.24238/13221-12-1-198","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Neuroscience","Score":null,"Total":0}
引用次数: 0
Abstract
Comorbidities like diabetes, arterial hypertension, or comorbidity factors such as
hypercholesterolemia is common in elderly persons and are associated with higher
risk of stroke. Since stroke afflicts mostly the elderly comorbid patients, it is highly desirable to test the efficacy of cell therapies in an appropriate animal stroke model. Animal models of stroke often ignore age and comorbidities frequently associated with aging, and this could be one of the explanations for unsuccessful bench-to-bedside translation of neuroprotective strategies. In order to mimic more closely the clinical condition, we have established a model of ischemic stroke in aged rats. Using this model, we showed that post-stroke angiogenesis is not impaired in the lesioned, aged brain and conclude that stroke in aged rodent models in reliable and more closely related to the human condition.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
