Broadly neutralizing antibodies against HIV-1 and concepts for application

IF 5.7 2区 医学 Q1 VIROLOGY Current opinion in virology Pub Date : 2022-06-01 DOI:10.1016/j.coviro.2022.101211
Henning Gruell , Philipp Schommers
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引用次数: 13

Abstract

Potent broadly neutralizing antibodies (bNAbs) targeting HIV-1 exhibit significant antiviral activity in humans. Recent advances have demonstrated that novel antibodies and bNAb combinations can effectively restrict the development of viral escape mutations. Moreover, passive immunization trials have provided proof-of-principle for bNAb-mediated prevention of infection with antibody-sensitive HIV-1 strains. In contrast, clinical studies investigating the activity of HIV-1 bNAbs on the latent reservoir failed to demonstrate substantial effects. Clinical adoption of HIV-1 bNAbs will require the development of more potent and broadly active antibodies as well as their implementation in optimized strategies to fully harness the capabilities of bNAbs. We review preclinical and clinical studies on HIV-1 bNAbs to highlight their potential and remaining limitations.

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抗HIV-1的广泛中和抗体及其应用概念
针对HIV-1的强效广泛中和抗体(bNAbs)在人类中表现出显著的抗病毒活性。最近的进展表明,新的抗体和bNAb组合可以有效地限制病毒逃逸突变的发展。此外,被动免疫试验已经为bnab介导的抗体敏感HIV-1毒株感染预防提供了原理证明。相比之下,研究HIV-1 bNAbs对潜伏库活性的临床研究未能显示出实质性的影响。HIV-1 bNAbs的临床应用将需要开发更有效和广泛活性的抗体,以及优化策略,以充分利用bNAbs的能力。我们回顾了HIV-1 bNAbs的临床前和临床研究,以强调其潜力和仍然存在的局限性。
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来源期刊
CiteScore
11.80
自引率
5.10%
发文量
76
审稿时长
83 days
期刊介绍: Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.
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