Gelatin-based scaffolds: An intuitive support structure for regenerative therapy

IF 4.7 3区 工程技术 Q2 ENGINEERING, BIOMEDICAL Current Opinion in Biomedical Engineering Pub Date : 2023-06-01 DOI:10.1016/j.cobme.2023.100452
Adib Bin Rashid , Nazmir-Nur Showva , Md Enamul Hoque
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引用次数: 5

Abstract

Advanced regenerative therapy aims to repair pathologically damaged tissue by cell transplantation in conjunction with supporting scaffolds. Gelatin-based scaffolds have attracted much attention in recent years due to their great bio-affinity that encourages the regeneration of tissues. Nowadays, by strengthening gelatin-based systems, cutting-edge methods like 3D bioprinting, freeze-drying, microfluidics and gelatin functionalization have shown excellent mimicry of natural tissue. The fabrication of porous gelatin-based scaffolds for wider tissue engineering applications including skin, cartilage, bone, liver, and cardiovascular is reviewed in this work. Additionally, the crosslinking procedures and the physicochemical characteristics of the gelatin-based scaffolds are also studied. Now, gelatin is considered one of the highest potential biomaterials for impending trends in which the gelatin-based scaffolds are used as a support structure for regenerative therapy.

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明胶支架——再生治疗的直观支撑结构
先进的再生疗法旨在通过细胞移植结合支架修复病理损伤的组织。近年来,明胶基支架因其具有促进组织再生的生物亲和性而受到广泛关注。如今,通过强化以明胶为基础的系统,3D生物打印、冷冻干燥、微流体和明胶功能化等尖端方法已经显示出对天然组织的出色模仿。本文综述了多孔明胶基支架在组织工程中的广泛应用,包括皮肤、软骨、骨骼、肝脏和心血管。此外,还研究了明胶基支架的交联过程和理化特性。现在,明胶被认为是最有潜力的生物材料之一,在即将到来的趋势中,明胶基支架被用作再生治疗的支持结构。
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来源期刊
Current Opinion in Biomedical Engineering
Current Opinion in Biomedical Engineering Medicine-Medicine (miscellaneous)
CiteScore
8.60
自引率
2.60%
发文量
59
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