Synergic effect of paclitaxel and cisplatin associated with gold nanoparticles on HeLa cervical cells

IF 2.2 4区工程技术 Q2 Chemistry Gold Bulletin Pub Date : 2022-01-22 DOI:10.1007/s13404-021-00305-5

Maria Laura Rodrigues Uggioni, Paulo Emilio Feuser, Jonathann Corrêa Possato, Maria Eduarda de Melo, Ellen De Pieri, Rodrigo Cercena, Alexandre Gonçalves Dal Bó, Maria Inês da Rosa, Ricardo Andrez Machado-de-Ávila

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引用次数: 4

Abstract

The combination of two or more chemotherapy drugs and nanotechnology has emerged as an effective strategy in the fight against cancer. Paclitaxel (PTX) and cisplatin show improved cytotoxic effects on being used together in the chemotherapy of various cancer types, than when used individually. However, these chemotherapy drugs have been shown to have numerous toxic effects in cancer patients. Therefore, the aim of this study was to evaluate the cytotoxicity of PTX and cisplatin associated with gold nanoparticles (AuNps) on HeLa cells containing multiple copies of human papillomavirus 18. AuNps were successfully synthesized with a mean size of 20 to 61 nm, polydispersity index ≥ 0.3, and negative surface charge. Together, PTX and cisplatin associated with AuNps showed a higher cytotoxic effect on HeLa cells than free drugs. The combination of PTX and cisplatin with AuNps potentiated their cytotoxic effects, inducing synergism between the treatments, resulting in HeLa cell death by apoptosis.

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紫杉醇和顺铂联合金纳米颗粒对HeLa宫颈细胞的协同作用

两种或多种化疗药物与纳米技术的结合已成为对抗癌症的有效策略。紫杉醇(PTX)和顺铂在各种癌症类型的化疗中联合使用比单独使用时显示出更好的细胞毒性作用。然而，这些化疗药物已被证明对癌症患者有许多毒性作用。因此，本研究的目的是评估PTX和顺铂与金纳米颗粒(AuNps)相关对含有人乳头瘤病毒18多拷贝的HeLa细胞的细胞毒性。成功合成的AuNps平均尺寸为20 ~ 61 nm，多分散性指数≥0.3，表面带负电荷。总之，PTX和顺铂与AuNps相关，对HeLa细胞的细胞毒性作用高于游离药物。PTX和顺铂联合AuNps增强了它们的细胞毒作用，诱导了治疗之间的协同作用，导致HeLa细胞凋亡死亡。图形抽象

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来源期刊

Gold Bulletin 工程技术-材料科学：综合

CiteScore

3.30

自引率

4.50%

发文量

审稿时长

3 months

期刊介绍： Gold Bulletin is the premier international peer reviewed journal on the latest science, technology and applications of gold. It includes papers on the latest research advances, state-of-the-art reviews, conference reports, book reviews and highlights of patents and scientific literature. Gold Bulletin does not publish manuscripts covering the snthesis of Gold nanoparticles in the presence of plant extracts or other nature-derived extracts. Gold Bulletin has been published over 40 years as a multidisciplinary journal read by chemists, physicists, engineers, metallurgists, materials scientists, biotechnologists, surface scientists, and nanotechnologists amongst others, both within industry and academia. Gold Bulletin is published in Association with the World Gold Council.