Signaling pathways involved in virulence and stress response of plant-pathogenic Fusarium species

Abstract

Fungal pathogens face similar stress conditions to those affecting plants and saprotrophic fungi. Therefore, mechanisms underlying fungal response to the stress factors may be well-conserved across various taxa. Saccharomyces cerevisiae was the most researched for signal transduction pathways but many of the pathways' components were later reported for filamentous fungi as well. The most widely studied pathways are those involving the G proteins, adenylate cyclase (cAMP) and mitogen-activated protein kinases (MAPKs). Apart from these, the target-of-rapamycin (TOR), calcium/calcineurin and cell wall integrity (CWI) pathways are of significant interest when stress response is considered. All these pathways were included in this review. It seems that the TOR-received signals are transferred to the CWI pathway, secondary metabolism and virulence. Specific and non-specific cellular responses of Fusarium species, triggered by signals received from the environment, were discussed, with particular focus on stress response and pathogenicity towards the plant host.