Serum Uric Acid Level in Preeclamptic Women Determine the Severity of Preeclampsia

Abstract

s: Background: Serum uric acid is a relatively insoluble metabolite of purine metalolism which is mainly secreted by the kidneys and the rate is dependant on renal blood flow . It increases in preeclampsia and studies show it may be marker of severe preeclampsia. Methods and materials: This cross sectional study was conducted in Dhaka Medical College Hospital in eclampsia ward of gynae & Obs department during the period from January 2010 to December 2011 with the objective to determine the serum uric acid level in preeclampsia, to compare the serum uric acid level between mild and sever preeclampsia and to find out any relationship of the serum uric acid level with hypertension in preeclampsia. The study group composed of 92 diagnosed case of preeclampsia patient. Out of the 92 cases, 42 had mild preeclampsia (group-A) and 50 had severe preeclampsia (group B). Result: The results of the study showed that the mean serum uric acid level was significantly higher in severe preeclampsia (6.91+1.02) compared to mild preeclampsia (4.99 + 0.80) and there is a positive and significant relationship of serum uric acid level with severity of hypertension in preeclampsia (p<.0001). Conclusion: There is significant association between serum uric acid level and severity of hypertension in Preeclampsia. Key word: Uric acid level in preeclampsia, Severity of preeclampsia. 1. Medical Officer, Department of Gynaecological Oncology, BSMMU. 2. Consultant, Department of Gynaecological Oncology, BSMMU. 3. Medical Officer, Department of Biochemistry and Molecular Biology, BSMMU. Address of Correspondence : Dr. Khairun Nahar, Medical Officer, Dept. of Obs & Gynae, BSMMU, Shahbag, Dhaka1000, Email: khairun_nahar58@yahoo.com, Mobile : 01717220429 Bangladesh J Obstet Gynaecol, 2017; Vol. 32(2): 67-72