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A Comparative Study on Feto-Maternal Outcome of GDM Treated by Either Insulin or Metformin 胰岛素与二甲双胍治疗GDM胎母结局的比较研究
Pub Date : 2020-09-01 DOI: 10.3329/bjog.v34i1.56669
Tania Noor, Tahmina Parvin, Sharmin Siddika, Farjana Begum, S. Banu, S. Tasnim, P. Jahan
Background: Gestational Diabetes Mellitus (GDM) is linked with amplified risk of variety of maternal and perinatal complications. There have been a number of studies comparing metformin with insulin in the management of GDM. Methods: A clinical trial (Quasi experimental) was conducted on fifty women with GDM at their 24 – 34 weeks of gestation with the aim to compare maternal and perinatal outcomes treated by either insulin or metformin. The study population were recruited from obstetrics and gynaecology outpatient department of Medical College for Women and Hospital, Uttara, Dhaka, from July 2012 to December 2012.The patients were divided into two groups (nonrandomized), 25 patients in each, and were subjected to either injection insulin or oral metformin medication. Results: The patients were grouped as insulin or metformin group. They were compared in terms of age, parity and developing maternal complications like preeclampsia (p=0.24), UTI (p=0.40), polyhydramnios (p=0.70). However, the incidence of preterm birth was higher among metformin group in comparison to insulin group (P=0.007).There was no significant difference between insulin and metformin group as regard to mode of delivery. The proportion of neonatal hypoglycemia in insulin group was higher than metformin group (P=0.46) but statistically not significant. Other neonatal outcomes such as macrosomia, birth asphyxia and hyperbillirubinaemia did not differ significantly between two groups. Conclusion: In women with GDM, treatment with metformin is associated with higher proportion of preterm birth than with insulin. Proportion of neonatal hypoglycemia is higher with insulin use. Bangladesh J Obstet Gynaecol, 2019; Vol. 34(1): 8-14
背景:妊娠期糖尿病(GDM)与各种孕产妇和围产期并发症的风险增加有关。已经有许多研究比较二甲双胍和胰岛素在GDM治疗中的作用。方法:对50名妊娠24-34周的GDM妇女进行了一项临床试验(准实验),目的是比较胰岛素或二甲双胍治疗的孕产妇和围产期结果。研究人群于2012年7月至2012年12月从达卡乌塔拉女子医学院和医院的妇产科门诊招募。患者被分为两组(非随机),每组25名患者,接受注射胰岛素或口服二甲双胍治疗。结果:患者分为胰岛素组或二甲双胍组。他们在年龄、产次和发生先兆子痫(p=0.24)、尿路感染(p=0.40)、羊水过多(p=0.70)等母体并发症方面进行了比较。然而,与胰岛素组相比,二甲双胍组的早产发生率更高(p=0.007)。胰岛素组和二甲双胍组在分娩方式方面没有显著差异。胰岛素组新生儿低血糖发生率高于二甲双胍组(P=0.46),但无统计学意义。其他新生儿结局,如巨大儿、出生窒息和高胆红素血症,在两组之间没有显著差异。结论:在患有GDM的女性中,二甲双胍治疗与早产的比例高于胰岛素治疗。使用胰岛素的新生儿低血糖发生率较高。孟加拉国妇产科杂志,2019;第34卷(1):8-14
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引用次数: 0
Relationship of Age and Different Histological Types of Ovarian Tumors 年龄与卵巢肿瘤不同组织学类型的关系
Pub Date : 2020-07-19 DOI: 10.3329/bjog.v32i2.48281
S. Begum, F. Begum, Nasimul Gani, F. Rahman, Farhana Jahan
Background: Ovarian tumours are common problem in gynaecology and have varied age of appearance of different histopathological types. Objective: This study was undertaken to find out the relationship of age and different histological types of ovarian tumors Methods: A retrospective study was carried out in the Department of Obstetrics and Gynaecology and Department of Pathology, Sir Salimullah Medical College and Mitford Hospital, Dhaka, during May 2010 and December 2014. Five hundred forty seven (547) cases of ovarian tumours were studied in respect to their age and histopathological appearance. Results: The range of age of patients with ovarian tumour was 11 – 82 years. About 63% malignant and 73% benign ovarian tumours were found in the age group of 20 – 49 yrs. About 31% malignant ovarian tumours and 15% Benign tumours occurred in menopausal woman (≤50 yrs.). Overall, mean age of presentation of ovarian tumours was 34.29± 12.84 yrs. Mean age of patients with malignant ovarian tumour was 40.29± 14.28 (median 40 yrs; mode 45 yrs.). Mean age of benign ovarian tumour was 34.69 ± 13.08 (median 34 yrs; mode 40yrs) and mean age for borderline tumours 32.75 ± 11.70 mm (median 33 yrs., mode 20 yrs.). Mean age of non tumour ovarian masses / cysts was 31.14± 10.76 yrs (median 29.5; mode 25.4). The difference of mean age of occurance of malignant and benign ovarian tumours were statistically significant P<0.00>. Dysgerminoma (mean age 23.5± 4.43) and yolk sac tumour (mean age 18 .00 ± 5.00 yrs) occurred in younger patients. Serous cyst adenocarcinoma, endometriod carcinoma and poorly differentiated carcinoma occurred around 45 years of age. Mean age of presentation of most of the benign ovarian tumours was between 30 – 37 yrs.; except thecoma which occurred in extremes of age. Conclusion: Most of the patients with malignant and benign ovarian tumours have presented in reproductive age adult women (20 – 49 yrs.); and some specific varieties of tumour (e.g. thecoma) presented in the extremes of age. Key word: ovarian tumour; age and ovarian tumour, benign ovarian tumour, malignant ovarian tumour, borderline ovarian tumour. Relationship of Age and Different Histological Types of Ovarian Tumors Shahnaz Begum et al. 100 till the patient has an acute emergency like torsion or rupture of a benign cyst. The worst is late presentation of a malignant ovarian tumour. Ovarian cancer accounts for 3% of all cancers in women; 80% of the ovarian tumors are benign, occurring in the age group of 20 to 45 years whereas malignant tumors are common in elderly women, between 45 to 65 years.1 Exact incidence in Bangladesh is not known but ovarian cancer is the sixth most common cancer among females of Bangladesh; fourth most common cause of death due to genital malignancies including breast. and continues to present at an advanced stage.[2] Incidence of ovarian malignancy is 4.7%; 5-year prevalence rate is 5.1% (7625 cases) and mortality rate is 5.1%.2 Estimated incidence, mor
背景:卵巢肿瘤是妇科常见的问题,具有不同年龄的不同组织病理学类型。目的:本研究旨在了解年龄与卵巢肿瘤不同组织学类型的关系。方法:回顾性研究于2010年5月至2014年12月在达卡Salimullah爵士医学院和Mitford医院妇产科和病理学系进行。对547例卵巢肿瘤的年龄和组织病理学表现进行了研究。结果:卵巢肿瘤患者的年龄范围为11–82岁。约63%的恶性和73%的良性卵巢肿瘤发生在20-49岁年龄组。约31%的恶性卵巢肿瘤和15%的良性肿瘤发生在更年期妇女(≤50岁)。总体而言,卵巢肿瘤的平均发病年龄为34.29±12.84岁。恶性卵巢肿瘤患者的平均年龄为40.29±14.28(中位数40岁;模式45岁)。良性卵巢肿瘤的平均年龄是34.69±13.08(中位数34岁;模式40岁),交界性肿瘤的平均年纪是32.75±11.70mm(中位数33岁,模式20岁)卵巢恶性和良性肿瘤的发生率具有统计学意义。生殖细胞瘤(平均年龄23.5±4.43)和卵黄囊肿瘤(平均年龄18.00±5.00岁)发生在年轻患者中。浆液性囊肿腺癌、子宫内膜样癌和低分化癌发生在45岁左右。大多数良性卵巢肿瘤的平均发病年龄在30-37岁之间。;除了发生在极端年龄的肿瘤。结论:卵巢良恶性肿瘤患者多为育龄成年女性(20~49岁);以及一些特定种类的肿瘤(如卵泡膜瘤)出现在极端年龄。关键词:卵巢肿瘤;年龄和卵巢肿瘤,良性卵巢肿瘤,恶性卵巢肿瘤,交界性卵巢肿瘤。年龄与卵巢肿瘤不同组织学类型的关系Shahnaz-Begum等人100,直到患者出现急性紧急情况,如良性囊肿扭转或破裂。最糟糕的是卵巢恶性肿瘤的晚期表现。癌症占女性所有癌症的3%;80%的卵巢肿瘤是良性的,发生在20至45岁的年龄组,而恶性肿瘤在45至65岁的老年妇女中很常见。1孟加拉国的确切发病率尚不清楚,但癌症是孟加拉国女性中第六常见的癌症;第四常见的死亡原因是生殖器恶性肿瘤,包括乳腺癌。并且继续呈现在高级阶段。[2] 卵巢恶性肿瘤的发生率为4.7%;5年患病率为5.1%(7625例),死亡率为5.1%。2东南亚妇女的估计发病率、死亡率和5年患病期分别为4.9%、5%和4.4%;占世界女性人口的比例分别为3.6%、4.3%和3.4%。[2] 良性卵巢囊肿可能发生在生命中的任何时候,但它们最常见于育龄期,约占卵巢肿瘤的90%。大多数良性肿瘤都是囊性的,发现实体成分会使恶性肿瘤的可能性更大。在印度大多数基于人口的癌症登记中,卵巢癌症是癌症的第三大发病点,仅次于宫颈癌和乳腺癌癌症。在该国不同地区,经年龄调整的卵巢癌症发病率在5.4-8之间(加尔各答为7.8%)/10万人口。3本研究旨在找出年龄与卵巢肿瘤不同组织学类型的关系
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引用次数: 2
A Study on Management of Premature Rupture of Membranes (PROM) 胎膜早破(PROM)的处理研究
Pub Date : 2020-07-19 DOI: 10.3329/bjog.v32i2.48280
A. Mondal, R. Roy, A. Mondal
Background: Premature rupture of membranes (PROM) is a common obstetric complication. Knowledge of etiopathogenesis, diagnosis, complications & management of PROM has increased due to extensive research in the recent past. Yet, there is no unanimous opinion regarding optimum management of PROM. The aim of the study was to observe the patients during labor and compare the latent period, duration of first stage of labor, modes of deliveries and the use of oxytocin and its outcome in PROM cases with controls. Materials and methods: In this study, the definition of PROM used is – rupture of fetal membranes before the onset of true labor pain. The minimum gestational age was taken to be 28 weeks. Diagnosis of PROM was mainly clinical. A cohort study was conducted in the Dept. of Obs & Gynae of KPL Medical College & Hospital, Kolkata on 100 cases of PROM and 100 cases of comparison group, over a period of one year. Results: It was observed that onset of labor was more rapid with increasing gestational age, use of oxytocin for induction & augmentation of labor & operative deliveries were higher in PROM cases. Conclusion: Individualized management of PROM cases depending on the gestational age and risk of complications is the best way to achieve a good feto-maternal outcome.
背景:胎膜早破是一种常见的产科并发症。由于近年来的广泛研究,对早膜PROM的发病机制、诊断、并发症和治疗的了解有所增加。然而,关于PROM的最佳管理尚无一致的意见。本研究的目的是观察胎膜早破患者的产程,比较胎膜早破与对照组的潜伏期、第一产程、分娩方式、催产素的使用及其结果。材料和方法:在本研究中,胎膜早破的定义是在真正的阵痛发生之前胎膜破裂。最小胎龄为28周。胎膜早破的诊断主要是临床诊断。在加尔各答KPL医学院和医院妇产科对100例胎膜早破和100例对照组进行了一项为期一年的队列研究。结果:随着胎龄的增加,胎膜早破的起产速度加快,使用催产素引产、助产及手术分娩的比例较高。结论:根据胎龄和并发症风险对胎膜早破进行个体化处理是获得良好胎母结局的最佳途径。
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引用次数: 0
A Case of Ruptured Rudimentary Horn of Uterus during Pregnancy 妊娠期原始子宫角破裂1例
Pub Date : 2020-07-19 DOI: 10.3329/bjog.v32i2.48284
U. Ruman, K. Khanam, S. Akhter, R. Karim
Pregnancy in a rudimentary horn of an unicornuate uterus is a rare and life threatening situation for mother and fetus. Usually pregnancy continues upto approximately 18-20 weeks of gestational age. Then it usually ruptures and severe haemorrhage ensues. Emergency laparotomy is the treatment of choice. Here we report a case of 36 years woman with secondary subfertility who has history of taking ovulation inducing drug. She presented with 20 weeks amenorrhoea with severe abdominal pain and hypovolemic shock. Urgent laparotomy was done and the diagnosis was confirmed. Fig.-1: USG showing empty uterine cavity. A Case of Ruptured Rudimentary Horn of Uterus during Pregnancy Ruman U et al. 122 Rudimentary horn was excised and uterus was repaired. Left salpingectomy was done. Patient was transfused with two units of blood during operation. Her postoperative period was uneventful. She was discharged on 10th postoperative day.
怀孕在一个原始角的独角子宫是一个罕见的和危及生命的情况下,母亲和胎儿。通常妊娠持续到大约18-20周的胎龄。然后它通常会破裂,随之而来的是严重的出血。紧急剖腹手术是治疗的首选。这里我们报告一个36岁的妇女继发性不孕谁有服用促排卵药物的历史。她表现为闭经20周,伴有严重腹痛和低血容量性休克。紧急开腹手术,确诊。图1超声心动图显示子宫空腔。妊娠期子宫残角破裂1例(Ruman U等,122)。行左侧输卵管切除术。手术中给病人输了两个单位的血。她的术后期间平安无事。术后第10天出院。
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引用次数: 0
Maternal Weight Gain and its Relationship with Birth Weight of Baby at Term 足月产妇体重增加及其与婴儿出生体重的关系
Pub Date : 2020-07-19 DOI: 10.3329/bjog.v32i2.48277
Shiffin Rijvi, S. Abbasi, F. Dewan, Sehereen Farhad Siddiqua, Anuradha Karmakar
Background: Perinatal health is influenced by maternal weight gain. Increase in obesity in population and excess weight during pregnancy may be different complications including large for gestational age fetus. As a result cesarean delivery has increased in prevalence. Maternal weight gain during the 2nd and 3rd trimesters is an important determinant of fetal growth Objective: To determine the relationship between maternal weight gain and birth weight of baby at term. Methodology : A cross sectional study was carried among 50 pregnant women at term in the Department of Obstetrics and Gynaecology, Shaheed Suhrawardy Medical College and Hospital and Anwer Khan Modern Medical College Hospital during the period of January 2013 to July 2013. Data were collected in pre-designed data collection sheet. Results: This study found maximum (36%) were age group 21-25 years followed by 28% were ≤20 years, 24% were between 26-30 years, 8% were between 31-35 years and only 4% were of 36-40 years. The average age was 25 years. Among these 50 pregnant women, 2 cases (4%) had BMI < 18.5, 15 cases (30%) had a BMI 18.5-24.9, 19 cases (38%) had a BMI 25-29.9 and 14 cases (28%) had a BMI ≥30. The mean birth weight was 2.77±0.33. kg. Mean weight gain was 10.72±3.72 Kg. Conclusion: This study showed that reasonable maternal weight gain significantly increased birth weight of the baby at term. Key word: Maternal weight gain in pregnancy, Birth weight of baby 1. Registrar Dept. of Obstetrics and Gynecology, Anwer Khan Modern Medical College Hospital 2. Assistant Professor, Dept. of Obstetrics and Gynecology, Anwer Khan Modern Medical College hospital 3. Head, Dept. of Obstetrics and Gynecology, Shaheed Suhrawardy Medical College and Hospital 4. Head Dept. of Obstetrics and Gynecology, Anwer Khan Modern Medical College Hospital 5. Registrar, Dept. of Obstetrics and Gynecology Delta Medical College Hospital Address of Correspondence: Dr. Shiffin Rijvi, Registrar Dept of obstetrics and gynecology Anwer Khan Modern Medical College Hospital Bangladesh J Obstet Gynaecol, 2017; Vol. 32(2): 79-83 Maternal Weight Gain and its Relationship with Birth Weight of Baby at Term Shiffin Rijvi et al. 80 underweight (BMI less than 19.8 kg/m2), normal weight (19.8 –26.0 kg/m2), overweight (26.1–29.0 kg/m2), and obese women (BMI more than 29.0 kg/ m2).2 Weight gain during pregnancy has been associated with high birth weight and measures of adiposity early in life. Because high birth weight predicts BMI later in life, these findings suggest that excessive weight gain during pregnancy could raise the long-term risk of obesity-related disease in offspring. High birth weight might also increase risk of other diseases later in life, including asthma, atopy, and cancer.3 Low weight gain in pregnancy is associated with increased risk of preterm delivery, particularly if women are underweight or of average weight before pregnancy. But still there is increasing evidence that higher weight gains during
这种担忧的存在是因为妊娠期体重增加与许多并发症有关,包括母体和胎儿。9 .巨大儿是一种主要的胎儿并发症,不论胎龄大小,出生时体重超过4000克的婴儿都有这种较高的体重与母亲和孩子的并发症有关。巨大胎儿最常见的并发症包括:宫内死亡风险增加、肥厚性心肌病、需要重症监护、肩关节难产、肱骨和锁骨骨折、胎就吸入、低血糖、新生儿高胆红素血症、面部和臂丛麻痹以及儿童期和成年期肥胖。10,11对母亲来说,最常见的并发症包括:剖宫产风险增加、头骨盆比例失调、分娩时间延长、软组织撕裂和产后出血本研究旨在确定产妇体重增加与足月新生儿出生体重之间的关系。材料与方法:横断面研究于2013年1月- 2013年7月在Shaheed Suhrawardy医学院附属医院妇产科和Anwer Khan现代医学院附属医院进行。50名孕妇参与了这项研究。本研究包括定期进行产前检查的健康足月孕妇(孕龄37周)。有高血压、先兆子痫、子痫、糖尿病、甲状腺功能障碍、肾炎的孕妇排除在研究之外。数据收集在预先设计的数据收集表中。作者在给药前编制了一份结构化问卷并进行了预测试。数据收集于住院住院的孕妇,为期6个月。数据采用面对面访谈的方式收集,资料来源为《孟加拉国妇产杂志》第32卷第2期81相关资料,并测量产妇产前体重和身高,分娩后测量新生儿体重。使用有效可靠的称重机测量母亲体重。母亲的身高是用身高秤测量的。一种有效可靠的新生儿称重机测定新生儿体重。每位患者均获得书面知情同意书。在同意之前,他们被解释了研究的目的和目的。保密和匿名得到了维护。
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引用次数: 1
BJOG yearly CME program Vol.32(2) 北京奥组委CME年度计划第32卷(2)
Pub Date : 2020-07-19 DOI: 10.3329/bjog.v32i2.48290
S. Khatun
Abstract Not Available Bangladesh J Obstet Gynaecol, 2017; Vol. 32(2) : 134-136
Abstract Not Available Bangladesh J Obstet Gynaecol,2017;第32卷(2):134-136
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引用次数: 0
Expectant Management of Severe Pre-eclampsia remote from term: Maternal and Perinatal outcome 早足月重度先兆子痫的预期治疗:孕产妇和围产期结局
Pub Date : 2020-07-19 DOI: 10.3329/bjog.v32i2.48276
K. Nahar, Hosna Akter, Summyia Nazmeen, S. Tasnim
Background: Management of severe pre eclampsia remote from term remains one of the most difficult challenges in obstetric practice. Expectant management of early onset severe pre eclampsia improves neonatal outcome. Methods: A prospective case series extending over five years peiod were recorded to evaluate the maternal and perinatal outcome of expectant management of severe preeclampsia presenting between 24-34 weeks of gestation in a tertiary referral center. All women (n=160) presenting with early onset (24-34 weeks of gestation) severe preeclampsia , where both the mother and the fetus were otherwise stable. Frequent clinical and biochemical monitoring of maternal status with careful blood pressure control. Foetal surveillance included six hourly foetal heart rate monitoring, bi weekly non stress test and weekly USG evaluation. Results: Mean number of days of prolongation of gestation was 6 days ( range 1-24days). The largest prolongation of pregnancy was recorded in patients with the lowest gestational age. Conservative management was associated with a 1.63% ( 17/160) intrauterine fetal loss rate. The days of pregnancy prolongation and perinatal mortality were significantly higher among those managed at <30 weeks. Increasing gestational age correlated with a reduction of RDS ( respiratory distress syndrome). Maternal morbidities were significantly higher among those managed at < 32 weeks. But there was no maternal mortality. Conclusion: Good perinatal outcome and less risk to mother can be achieved at 30-34 weeks gestation. Bangladesh J Obstet Gynaecol, 2017; Vol. 32(2) : 73-78
背景:管理严重子痫前期远足月仍然是产科实践中最困难的挑战之一。早发严重子痫前期的预期管理改善新生儿结局。方法:在一个三级转诊中心,对妊娠24-34周的严重子痫前期患者的孕妇和围产期结局进行了为期5年的前瞻性病例记录。所有妇女(n=160)表现为早发(妊娠24-34周)严重先兆子痫,其中母亲和胎儿在其他方面均稳定。经常进行临床和生化监测,并注意控制血压。胎儿监测包括6小时胎儿心率监测、2周无应激试验和每周USG评估。结果:平均妊娠延长天数为6天(范围1 ~ 24天)。妊娠延长最长的是最低胎龄的患者。保守处理与1.63%(17/160)的宫内胎儿丢失率相关。妊娠延长天数和围产期死亡率明显高于<30周的孕妇。胎龄增加与RDS(呼吸窘迫综合征)的减少相关。在妊娠< 32周的孕妇中,产妇发病率显著增高。但是没有产妇死亡率。结论:妊娠30 ~ 34周围产儿结局良好,对母亲的危害较小。孟加拉国妇产科杂志,2017;Vol. 32(2): 73-78
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引用次数: 0
Society News Vol.32(2) 社会新闻第32卷(2)
Pub Date : 2020-07-19 DOI: 10.3329/bjog.v32i2.48288
S. Khatun
Abstract Not Available Bangladesh J Obstet Gynaecol, 2017; Vol. 32(2) : 130-132
Abstract Not Available Bangladesh J Obstet Gynaecol,2017;第32卷(2):130-132
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引用次数: 0
Aspirin to Prevent Preeclampsia 阿司匹林预防先兆子痫
Pub Date : 2020-07-19 DOI: 10.3329/bjog.v32i2.48282
F. Begum, T. Chowdhury
Background: Pre-eclampsia is a major cause of mortality and morbidity during pregnancy and childbirth. There are recommendations on use of medications to prevent preeclampsia, including low dose aspirin. Objective: The objective of this review is to discuss role of aspirin in reducing the incidence and maternal mortality and morbidity due to preeclampsia including its dose and duration
背景:先兆子痫是妊娠和分娩期间死亡和发病的主要原因。有关于使用药物预防先兆子痫的建议,包括低剂量阿司匹林。目的:本综述的目的是讨论阿司匹林在降低先兆子痫的发病率、孕产妇死亡率和发病率方面的作用,包括其剂量和持续时间
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引用次数: 1
International News Vol.32(2) 国际新闻第32卷(2)
Pub Date : 2020-07-19 DOI: 10.3329/bjog.v32i2.48289
S. Khatun
Abstract Not Available Bangladesh J Obstet Gynaecol, 2017; Vol. 32(2) : 133
孟加拉妇产杂志,2017;Vol. 32(2): 133
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引用次数: 0
期刊
Bangladesh Journal of Obstetrics and Gynecology
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