{"title":"The role of serum fucose, protein bound fucose and other biomarkers in patients with rheumatoid arthritis","authors":"A. Joda","doi":"10.26903/MMJ.V16I3.111","DOIUrl":null,"url":null,"abstract":"Background: Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that principally attacks synovial joints. Aims: To evaluate the status of serum fucose and protein bound fucose, anti-CCP, TNF-α and RF in serum of RA patients. Subjects and methods: The study has included 30 patients with early RA (with disease duration 1 year) diagnosed according to the 2010 EULAR criteria (25 females, 5 males) with age range (30-60) and 28 healthy control individuals (22 females,6 males) with age range (30-55), who were age and sex matching with patients. Results: Levels of total serum fucose and protein bound fucose significantly decrease in RA patients than healthy control, while anti-CCP, TNF-α, RF, CRP and ESR significantly increase in RA patients than healthy control. Levels of total serum fucose, protein bound fucose & ACCP were not significant between three stages of activity in late & early RA patients. The level TNF-α & RF were significant only in very active cases in late RA, while not significantly in all cases of early RA. Positive correlation was found between ACCP & ESR in RA patients & early RA patients. Positive correlation found between TSF & PBF, negative correlation found between TNF-α & ESR in late RA patients. Positive correlation found between ACCP & ESR, CRP & ESR in early RA patients. Conclusions: This study illustrate that total serum fucose and protein bound fucose aid to diagnosis RA patient. Also Anti-CCP is a good & specific marker for diagnosis of RA,it is a good prognostic and as index test of severity","PeriodicalId":33069,"journal":{"name":"mjl@ lmstnSry@ lTby@","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"mjl@ lmstnSry@ lTby@","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.26903/MMJ.V16I3.111","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that principally attacks synovial joints. Aims: To evaluate the status of serum fucose and protein bound fucose, anti-CCP, TNF-α and RF in serum of RA patients. Subjects and methods: The study has included 30 patients with early RA (with disease duration 1 year) diagnosed according to the 2010 EULAR criteria (25 females, 5 males) with age range (30-60) and 28 healthy control individuals (22 females,6 males) with age range (30-55), who were age and sex matching with patients. Results: Levels of total serum fucose and protein bound fucose significantly decrease in RA patients than healthy control, while anti-CCP, TNF-α, RF, CRP and ESR significantly increase in RA patients than healthy control. Levels of total serum fucose, protein bound fucose & ACCP were not significant between three stages of activity in late & early RA patients. The level TNF-α & RF were significant only in very active cases in late RA, while not significantly in all cases of early RA. Positive correlation was found between ACCP & ESR in RA patients & early RA patients. Positive correlation found between TSF & PBF, negative correlation found between TNF-α & ESR in late RA patients. Positive correlation found between ACCP & ESR, CRP & ESR in early RA patients. Conclusions: This study illustrate that total serum fucose and protein bound fucose aid to diagnosis RA patient. Also Anti-CCP is a good & specific marker for diagnosis of RA,it is a good prognostic and as index test of severity