Psoriatic erythroderma: comparative patient profile and association with psoriatic arthritis

Q4 Medicine Vestnik dermatologii i venerologii Pub Date : 2022-10-26 DOI:10.25208/vdv1328
E. Bogdanova
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引用次数: 1

Abstract

Background: Psoriatic erythroderma is rare and the most severe form of psoriasis characterized by involvement of 80-90% of body surface area. Aims: to compare clinical and demographic characteristics of patients with psoriasis, depending on presence of psoriatic erythroderma in medical history; to assess the association between psoriatic arthritis and a history of psoriatic erythroderma. Materials and methods: patients aged 18 years and older with a duration of psoriasis of 10 years, from the psoriasis patients registry were included. Comparison of continuous quantitative variables was performed using t-test or Mann-Whitney U-test. The 2 test or Fisher's exact test was used to compare qualitative binary variables. The odds ratio of psoriatic arthritis in patients with and without a history of psoriatic erythroderma was calculated, unadjusted and adjusted for other independent variables. Results: The number of patients included in the analysis was 1,870. A history of psoriatic erythroderma (PE) had 227 (12.1%) of them. There were no significant differences in patient age at inclusion to the registry (47.113.1 years vs. 47.713.3 years), and prevalence of PE among men and women (12.6% vs. 11. 4%). Higher prevalence of arterial hypertension (47.9% vs 32.7%), angina pectoris (6.4% vs. 1.9%), myocardial infarction (3. 2% vs. 1.0%), biliary dyskynesia (14.3% vs. 3.9%), fatty liver (12.2% vs. 7.7%), cholelithiasis (8. 6% vs. 3.6%), and toxic liver disease (2.2% vs. 0.5%) among patients with vs without history of PE was found. Psoriatic arthritis was diagnosed in 67.0% patients with a history of psoriatic erythroderma. The odds of having psoriatic arthritis in patients with a history of psoriatic erythroderma were 4 times higher than in patients without erythroderma: 4.043 [2.975-5.493]. When adjusted for sex, age, duration of psoriasis, and body mass index, the odds ratio and statistical significance were maintained: 4.064 [2.939-5.619]. Conclusions: compared to patients without PE those with a history of psoriatic erythroderma have a greater comorbidity burden: a higher prevalence of cardiovascular diseases, diseases of the liver and biliary tract. A significant association between psoriatic arthritis and a history of PE was established.
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银屑病红皮病:比较患者概况及其与银屑病关节炎的关系
背景:银屑病红皮病是一种罕见且最严重的银屑病,其特征是累及体表面积的80-90%。目的:比较银屑病患者的临床和人口学特征,根据病史是否存在银屑病红皮病;评估银屑病关节炎与银屑病红皮病病史之间的关系。材料和方法:研究对象为年龄在18岁及以上,病程在10年以上的银屑病患者。连续定量变量比较采用t检验或Mann-Whitney u检验。采用2检验或Fisher精确检验比较定性二元变量。计算有和没有银屑病红皮病史的患者患银屑病关节炎的优势比,未经调整并根据其他自变量进行调整。结果:纳入分析的患者数量为1870例。银屑病红皮病(PE)病史227例(12.1%)。纳入登记的患者年龄(47.113.1岁对47.713.3岁)和PE在男性和女性中的患病率(12.6%对11.3%)无显著差异。4%)。动脉性高血压(47.9%对32.7%)、心绞痛(6.4%对1.9%)、心肌梗死(3.7%)患病率较高。(2% vs. 1.0%),胆道性记忆障碍(14.3% vs. 3.9%),脂肪肝(12.2% vs. 7.7%),胆石症(8.7%)。在有PE病史和没有PE病史的患者中发现了中毒性肝病(2.2%对0.5%)。67.0%有银屑病红皮病史的患者诊断为银屑病关节炎。有银屑病红皮病病史的患者患银屑病关节炎的几率是无红皮病患者的4倍:4.043[2.975-5.493]。经性别、年龄、牛皮癣病程、体重指数等因素校正后,优势比为4.064[2.939-5.619],差异无统计学意义。结论:与没有PE的患者相比,有银屑病红皮病病史的患者有更大的合并症负担:心血管疾病、肝脏疾病和胆道疾病的患病率更高。银屑病关节炎与PE病史之间存在显著关联。
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来源期刊
CiteScore
0.80
自引率
0.00%
发文量
40
审稿时长
8 weeks
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