Diabetic Neuropathic Pain has Endogenous Modulation Depending on the Intensity of Physical Exercise: A Brief Communication

William Pereira Valadares, D. L. de Almeida
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Abstract

The opioidergic systems play a key role in endogenous modulation of neuropathic pain, given that Naloxone, a nonselective opioid receptors antagonist at a dose of 100 µg, reverted the antihyperalgesia caused by physical exercise demonstrated in our previous study. Due to the lack of relates regarding the control variables of physical exercise and endogenous modulation in neuropathic diabetic pain, we investigated if such modulation is exercise intensity dependent.
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糖尿病神经性疼痛的内源性调节取决于体育锻炼的强度:一个简短的交流
阿片系统在神经性疼痛的内源性调节中发挥着关键作用,因为纳洛酮是一种剂量为100µg的非选择性阿片受体拮抗剂,可逆转我们先前研究中证明的体育锻炼引起的抗高镇痛作用。由于缺乏关于体育锻炼的控制变量和神经性糖尿病疼痛的内源性调节的相关性,我们研究了这种调节是否依赖于运动强度。
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