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The Etiology of Abnormal TSH in Veterans Cared by a VA Medical Center - One High Serum Thyrotropin is Associated with Higher 5-Years Mortality. 退伍军人医疗中心护理的退伍军人促甲状腺激素异常的病因 - 血清促甲状腺激素偏高与较高的 5 年死亡率有关。
Pub Date : 2023-03-01 Epub Date: 2023-05-20
Sing-Yung Wu, Mark Chambers, Mazhar Khan, Maureen Chinweze, Thao-My Cao, Haibo Zhao
<p><strong>Objective: </strong>By analyzing the etiology of abnormal TSH in randomly selected veteran patients, we set our heart on improving future clinical care/management of the clinical/subclinical hyper- and hypothyroidism in the aging veteran population.</p><p><strong>Methods: </strong>A total of 1100 patients' charts in alphabetical order were selected. Excluded cases of insufficient information, 897 patients' charts were reviewed and analyzed for causes of abnormal TSH. Among them, 602 for the cause of low TSH (below 0.55 uU/mL) and 295 for high TSH (above 4.78 uU/mL) were reviewed retrospectively.</p><p><strong>Findings: </strong>Among the 1100 patients selected, 680 (61.8%) were 60 y or older (female=44, 6.8%); 420 were under 60 y (female=80, 19.0%); significantly more female patients were found in the younger age group (P<0.001). After excluding patients with insufficient data, the most common cause of suppressed TSH is iodine-induced, CT iodinated contrast and betadine use caused 35.0% in the older group (n=126) compared to 23.6% in the younger group(n=57) (P = 0.027). The significant difference is that older veterans received more contrast CTs (P < 0.05 compared to the younger group). In both age groups with concurrent FT4 study, we found four high FT4 among 90 studies, 4.4% overt hyperthyroidism. The second most common cause of suppressed TSH is due to thyroid hormone (TH) replacement in the older group (119 patients, 33.1%) with age > 60y, significantly more frequent compared to the younger group, P<0.001. There is significantly more overt hyperthyroidism, 27.8/%, than the iodine-load induced suppression of TSH, P<0.001, due to 17 patients on TSH suppression therapy after total thyroidectomy for thyroid cancer. Among the 295 patients with elevated TSH, the most common cause of high TSH was due to hypothyroidism on T4 replacement: a total of 128 (59.3%) in the older group (N=216) is, similar to 47 (59.5%) in the younger group (N=79). In both age groups, there were 139 patients with concomitant FT4 measurement; 17 overt hypothyroidism were found, 12.2%. No significant difference is seen in the two age groups. The next most common causes of elevated TSH are CT contrast infusion, 23 (10.6%) in the older group and 7 (8.9%) in the younger group. We find high TSH is associated with a higher death rate of 101/238 (42.4%) in a 5-year follow-up (from 2016 to 2021), as compared to low TSH of 68/238 (28.6%), in the older age group, p<0.03; both were significantly higher than the age- and sex-matched general US population, 19.7%, P<0.01.</p><p><strong>Conclusion: </strong>Even though most, ~ 90%, were subclinical, the suppressed and elevated TSH are associated with severe consequences in CV/CNS and immune-suppression complications in aging veterans. Therefore, cautious use (and more frequent check of TSH) of TH replacement and CT contrast in aging veterans is recommended. The alarming increase in 5 years death rate in older patients with elevat
目的:通过分析随机抽取的退伍军人患者促甲状腺激素异常的病因,我们将致力于改善未来对老龄退伍军人群体中临床/亚临床甲状腺功能亢进症和甲状腺功能减退症的临床护理/管理:方法:按字母顺序选取了 1100 份患者病历。方法:按字母顺序选取了 1100 份患者病历,排除了信息不足的病例,对 897 份患者病历进行了审查,并分析了 TSH 异常的原因。回顾性分析了其中 602 例 TSH 偏低(低于 0.55 uU/mL)和 295 例 TSH 偏高(高于 4.78 uU/mL)的原因:在选取的 1100 例患者中,680 例(61.8%)年龄在 60 岁或以上(女性=44 例,占 6.8%);420 例年龄在 60 岁以下(女性=80 例,占 19.0%);年轻组中女性患者明显较多(P 60y,与年轻组相比,女性患者明显较多):尽管大多数(约 90%)患者为亚临床症状,但 TSH 的抑制和升高与老龄退伍军人的 CV/CNS 和免疫抑制并发症的严重后果有关。因此,建议在老龄退伍军人中慎用(并更频繁地检查 TSH)TH 替代品和 CT 对比剂。TSH升高的老年患者5年内死亡率的惊人增长值得进一步研究。
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引用次数: 0
Obesity and Chrono-Nutrition 肥胖和时间营养
Pub Date : 2022-05-30 DOI: 10.31579/2640-1045/115
A. Nikkhah
The objective of this article was to describe obesity mechanisms and why obesity and meal properties during a circadian phase are interrelated. Obesity remains a major challenge globally. The increasing rates of obesity and diabetes indicate that current perspectives on obesity etiology are not adequately explanatory. The common view on obesity is energy balance model (EBM), suggesting that energy is stored as fat when overconsumed. However, since EBM is driven by physics, biochemical pathways of fat storage are overlooked. Insulin is secreted by increased blood glucose which drives positive energy balance and thus fat deposition. Such pathways present an innovative concept known as carbohydrate insulin model (CIM). This model might offer a more mechanistic perception into obesity development. Considering that glucose metabolism possesses circadian rhythmicity, CIM and chrono-nutrition may be interconnected. Preventing glycemic load through limiting carbohydrate-rich diets intake and care of meal timing would benefit obesity and diabetes prevention strategies. In conclusion, energy source and chrono-nutrition should be contemplated together as key factors influencing energy partitioning and fat deposition in the modern human.
这篇文章的目的是描述肥胖的机制和为什么肥胖和膳食特性在昼夜节律阶段是相互关联的。肥胖仍然是全球面临的一大挑战。肥胖和糖尿病发病率的上升表明,目前关于肥胖病因的观点还不能充分解释。关于肥胖的普遍观点是能量平衡模型(EBM),认为能量在过度消耗时以脂肪的形式储存。然而,由于EBM是由物理驱动的,因此忽略了脂肪储存的生化途径。胰岛素是由升高的血糖分泌的,它驱动正能量平衡,从而导致脂肪沉积。这种途径提出了一个创新的概念,即碳水化合物胰岛素模型(CIM)。这个模型可能为肥胖的发展提供一个更机械的认识。考虑到葡萄糖代谢具有昼夜节律性,CIM和时营养可能相互关联。通过限制富含碳水化合物的饮食摄入和注意进餐时间来预防血糖负荷将有利于肥胖和糖尿病的预防策略。综上所述,能量来源和时间营养应被视为影响现代人能量分配和脂肪沉积的关键因素。
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引用次数: 0
Refractory Hypoglycemia due to Humulin Humulin引起的难治性低血糖
Pub Date : 2022-05-30 DOI: 10.31579/2640-1045/109
Mao Tang, Lu Cixin
Humulin 70/30 insulin is an intermediate acting medication used for treatment diabetes mellitus. According to systematic review and there have been forty four case reports of overdoses with different types of insulin. We present a unique case of insulin Humulin 70/30 overdose due to suicidal attempt that presented with persistent hypoglycemia and required prolonged hospital treatment. A47 years old female patient presented to the emergency department due to decreased level of consciousness after self -administration of 2000 international unit Humulin insulin 70/30 suicidal attempt. In the emergency department patient treated with 250 ml D10% then shifted to the medical department. The patient continue treatment with dextrose 10% 200 ml/hour as continuous infusion, unfractionated heparin 7500 international unit/12 hour, hydrocortisone 100mg /6 hours, octreotide 100 microgram /8 and glucagon 1 mg . On the fourth day all medication and D10% stopped and the patient still under observation then discharged on will general condition without hypoglycemia attacks. A single high overdose of Humulin insulin can present with prolonged persistent hypoglycemia that is refractory to D10% alone. All physicians should know the guidelines to treat severe form of hypoglycemia and when to admit into medical department or intensive care unit with follow up for blood glucose and serum electrolyte monitoring.
Humulin 70/30胰岛素是一种用于治疗糖尿病的中效药物。根据系统综述,已有44例不同类型胰岛素过量的病例报告。我们报告了一个独特的案例,Humulin 70/30胰岛素过量是由于自杀未遂,表现为持续低血糖,需要长期住院治疗。A47岁女性患者因自我服用2000国际单位Humulin胰岛素70/30自杀未遂后意识水平下降而就诊于急诊科。在急诊科,接受250毫升D10%治疗的患者随后转到医疗部门。患者继续使用10%葡萄糖200 ml/小时连续输注、普通肝素7500国际单位/12小时、氢化可的松100mg/6小时、奥曲肽100微克/8和胰高血糖素1 mg进行治疗。第四天,所有药物和D10%停止,患者仍在观察中,然后出院,一般情况下没有低血糖发作。Humulin胰岛素的单次高剂量过量可导致长期持续低血糖,这对D10%的单独用药是难治的。所有医生都应该知道治疗严重低血糖的指南,以及何时进入医疗部门或重症监护室,并进行血糖和血清电解质监测。
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引用次数: 0
A Novel Gut-Orchestrated Exercise Theory on Obesity and Cancer Prevention 一种关于肥胖和癌症预防的新型肠道运动理论
Pub Date : 2022-05-30 DOI: 10.31579/2640-1045/117
A. Nikkhah
A novel gastrointestinal tract (gut) mediated exercise theory was developed to explain how highly disciplined physical activity can help prevent obesity and cancer. The gut serves the modern human body as another brain. The gut microbiota plays crucial regulatory roles in determining the health of the gut itself and entire body. Adequate exercise has been recommended to increase energy expenditure and reduce fat deposition, especially visceral adiposity. This article presents a gut-brain axis related theory based upon which with adequately intense and regular physical activity, the gut does assimilate foods and nutrients more effectively. Thus, the amount and flow of excreta are optimized. As such, the excretion of unhealthy compounds such as cholesterol, fatty acids, and to some extent starch increase. As a result, hepatic load of nutrients decrease. Consequently, the entire body tissues experience a relief in the time-consuming and energy-burning process of metabolite turnover and detoxification. Therefore, regular intense exercise does not only reduce unhealthy nutrient deposition, it can also decrease appetite and nutrient intake. This theory should permit innovative research to formulate new gut-centered public recommendations regarding the importance of adequate regular exercise to help prevent obesity and cancer and associated metabolic complexities.
开发了一种新的胃肠道(肠道)介导的运动理论,以解释高度自律的体育活动如何有助于预防肥胖和癌症。肠道作为另一个大脑为现代人体服务。肠道微生物群在决定肠道自身和整个身体的健康方面发挥着至关重要的调节作用。建议进行充分的运动,以增加能量消耗,减少脂肪沉积,尤其是内脏脂肪。本文提出了一种与肠脑轴相关的理论,基于该理论,通过充分剧烈和有规律的体育活动,肠道确实能更有效地吸收食物和营养。因此,排泄物的数量和流量得到了优化。因此,胆固醇、脂肪酸和淀粉等不健康化合物的排泄量会增加。结果,肝脏的营养物质负荷减少。因此,整个身体组织在代谢产物转换和解毒的耗时和能量消耗过程中都会得到缓解。因此,经常剧烈运动不仅可以减少不健康的营养沉积,还可以降低食欲和营养摄入。这一理论应允许进行创新研究,以制定新的以公众为中心的建议,说明充分定期锻炼的重要性,以帮助预防肥胖和癌症以及相关的代谢复杂性。
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引用次数: 0
Glp-1 Analogs for the Treatment of Obesity and Diabetes Glp-1类似物治疗肥胖和糖尿病
Pub Date : 2022-05-30 DOI: 10.31579/2640-1045/116
B. J., Tapper X
Currently the prevalence of obesity and diabetes is increasing throughout the world. The unsatisfactory long-term results observed in the treatment of both are due to their complex pathophysiologies and the difficulties related to maintaining lifestyle changes. From the knowledge of the incretin effect and its alteration in patients with type 2 diabetes mellitus, GLP-1 receptor agonists arise, molecules with high structural homology with native GLP-1. Scientific evidence supports its use for the long-term treatment of diabetes, especially in the presence of associated cardiovascular and/or renal failure. In 2009, the use of liraglutide for patients with diabetes was approved in Europe, and in 2014 it was signed for the first time in the United States to treat obesity, since it was observed that the use of these drugs causes significant weight loss.
目前,肥胖和糖尿病的患病率在全世界范围内呈上升趋势。在这两种疾病的治疗中观察到的不令人满意的长期结果是由于其复杂的病理生理学和与维持生活方式改变相关的困难。根据对2型糖尿病患者肠促胰岛素作用及其改变的了解,出现了GLP-1受体激动剂,其分子与天然GLP-1具有高度结构同源性。科学证据支持其用于糖尿病的长期治疗,特别是在存在相关心血管和/或肾衰竭的情况下。2009年,利拉鲁肽在欧洲被批准用于糖尿病患者,2014年,它在美国首次被签署用于治疗肥胖,因为人们观察到使用这些药物会显著减轻体重。
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引用次数: 0
Herbal Supplementation to Improve Management of Diabetes Mellitus Patient Care: Current Progress 中药补充改善糖尿病患者护理管理的最新进展
Pub Date : 2022-05-30 DOI: 10.31579/2640-1045/120
A. K., Ghouini A, G. A, I. H.
Diabetes affects millions of patients round the world, with dancing complications, inclusion, cardiovascular diseases, neuropathie and rétinopathie. Howe ver, the progression of type 2 diabetes mellites might be slowed down and its health impact limited. Nevetheless, current anti-diabetic treatments have limitations and is not Enugu to significantly improve the cardiovascular prognosis of diabetic patients. This work focus on herbal supplement and nutrition as potentiel thérapies for type 2 diabètes mellitus. Actually, Herbal and nutritional supplémentation is required in the management of diabétiques patients, a binding shared unanimously by scientists. Récent diabetologists have come to the évidence that a therapeutic supplement consisting of nutrients and herbal is necessary to optimize the treatment of diabetes. The treatment of Type 2 diabetes mellitus, winch is very often Associate with overweight, is based on hygiene and dietetic measures and, where appropriate, on taking oral antidiabetics. This review describes the therapeutic arsenal of conventionnel oral antidiabetic drugs and emphasizes on innovative therapeutic option introduction herba medicine and nutrition to the management of diabetic patients. Recent studies showed interesting potential in the reduction of blood sugar for many herbal for example Cinnamon, also berberine has been linked to the reduction of blood glucose levels, insulin levels and showed to be as effective as metformin, the most commonly prescribed drug for diabetics, at controlling blood sugar levels in diabetics. Moreover, a medicinal plant or herbal mixture can provide multi-targeted therapeutic action due to its complex chemical composition with hundreds of active ingredients such as oligosaccharides, alkaloids, polyphenols, flavonoids, tannins and at the same time ensure safety for the patients. We conclude by the fact that herbal and nutritional supplementation can bring major and promising progress in order to improve the patient care, by slowing the progression of type 2 diabetes and limiting its complications.
糖尿病影响着全世界数百万患者,包括舞蹈并发症、包容性、心血管疾病、神经病理性和视网膜病变。然而,2型糖尿病的进展可能会减缓,其对健康的影响也有限。尽管如此,目前的抗糖尿病治疗仍有局限性,Enugu并不能显著改善糖尿病患者的心血管预后。这项工作的重点是草药补充剂和营养作为治疗2型糖尿病的潜在疗法。事实上,在糖尿病患者的管理中需要草药和营养支持,这是科学家们一致同意的。糖尿病专家已经证明,由营养素和草药组成的治疗补充剂对于优化糖尿病治疗是必要的。2型糖尿病的治疗通常与超重有关,基于卫生和饮食措施,并在适当的情况下口服抗糖尿病药物。这篇综述描述了Conventionel口服抗糖尿病药物的治疗库,并强调了创新的治疗方案,将草药和营养引入糖尿病患者的管理中。最近的研究表明,许多草药(如肉桂)在降低血糖方面具有有趣的潜力,黄连素也与降低血糖水平和胰岛素水平有关,并且在控制糖尿病患者血糖水平方面与糖尿病患者最常用的处方药二甲双胍一样有效。此外,药用植物或草药混合物具有复杂的化学成分,含有数百种活性成分,如低聚糖、生物碱、多酚、类黄酮、单宁,可提供多靶向治疗作用,同时确保患者的安全。我们的结论是,草药和营养补充剂可以通过减缓2型糖尿病的进展和限制其并发症,为改善患者护理带来重大而有希望的进展。
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引用次数: 0
Lifestyle Modification Therapy in Diabetes Disease: A Review Article 糖尿病的生活方式改变疗法:一篇综述文章
Pub Date : 2022-01-07 DOI: 10.31579/2640-1045/112
Nanda Rachmad Putra Gofur, Aisyah Rachmadani Putri Gofur, Soesilaningtyas Soesilaningtyas, Rizki Nur Rachman Putra Gofur, M. Kahdina, Hernalia Martadila Putri
Introduction: Diabetes mellitus (DM) is a metabolic disease characterized by high blood glucose levels (hyperglycemia) resulting from disturbances in insulin secretion, insulin action or both. Insulin is a hormone produced by pancreatic beta cells, which is needed to utilize glucose from digested food. Comprehensive care is taken to treat patients with either prediabetes or diabetes. Diabetes management includes lifestyle interventions along with pharmacologic therapy and routine blood glucose monitoring. So that a decrease in blood glucose can occur and can be stable for a long time. Discussion:Lifestyle modification is an economical treatment that saves costs to prevent or delay the onset of diabetes. On the other hand, nutritional management provided by a dietitian is also recommended. Moderate weight loss goals are an important component of diabetes prevention and treatment, as large body weight can increase blood glucose levels, and can also have an increasing impact on blood pressure and cholesterol levels. Weight loss can be achieved through a balanced diet, with total control of calories and free carbohydrates. However, for diabetic patients following a low-carbohydrate diet, they should be informed about possible side effects such as hypoglycemia, headaches and constipation. Other studies have suggested the consumption of complex dietary fiber and whole grains to improve blood sugar control. Greater adherence to diet combined with light physical activity was associated with a lower likelihood of diabetes after adjusting for various factors. Conclusion:Lifestyle modification is a fairly cost-effective treatment to prevent or delay the onset of diabetes, with a risk reduction of about 58% in 3 years. It is strongly recommended by the ADA that patients with IGT, IFG or HbA1C levels of 5.7-6.4% be counseled on lifestyle changes such as diet and exercise. On the other hand, nutritional management provided by a dietitian is also recommended.
引言:糖尿病(DM)是一种代谢性疾病,其特征是由胰岛素分泌、胰岛素作用或两者兼有引起的高血糖水平(高血糖)。胰岛素是胰腺β细胞产生的一种激素,需要它来利用消化食物中的葡萄糖。对糖尿病前期或糖尿病患者进行综合护理。糖尿病管理包括生活方式干预、药物治疗和常规血糖监测。因此,血糖可以下降,并且可以长期稳定。讨论:改变生活方式是一种经济的治疗方法,可以节省预防或延缓糖尿病发作的费用。另一方面,也建议由营养师提供营养管理。适度的减肥目标是糖尿病预防和治疗的重要组成部分,因为大体重会增加血糖水平,也会对血压和胆固醇水平产生越来越大的影响。减肥可以通过均衡饮食来实现,完全控制热量和游离碳水化合物。然而,对于低碳水化合物饮食的糖尿病患者,应告知他们可能的副作用,如低血糖、头痛和便秘。其他研究表明,食用复合膳食纤维和全谷物可以改善血糖控制。在对各种因素进行调整后,更坚持饮食并进行轻度体育活动与患糖尿病的可能性降低有关。结论:改变生活方式是预防或延缓糖尿病发作的一种相当划算的治疗方法,3年内风险降低约58%。ADA强烈建议IGT、IFG或HbA1C水平为5.7-6.4%的患者就饮食和锻炼等生活方式的改变进行咨询。另一方面,也建议由营养师提供营养管理。
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引用次数: 0
Type 1 Brugada pattern induced by DKA DKA诱导的1型Brugada模式
Pub Date : 2022-01-07 DOI: 10.31579/2640-1045/106
Drew Johnson
A 25-year-old man with a past medical history of type 1 diabetes presented to the emergency department with 2 days of progressive abdominal pain, nausea, and vomiting after stopping insulin. His heart rate was 125 and the respiratory rate was 26. The glucose was 832 mg/dl, the potassium was 6.6 mmol/L, the beta-hydroxybutyrate was 111.8 mg/dl, and the pH was 6.95.
25岁男性,既往有1型糖尿病病史,停药后2天出现进行性腹痛、恶心和呕吐,就诊于急诊科。他的心率是125,呼吸频率是26。葡萄糖832 mg/dl,钾6.6 mmol/L, β -羟基丁酸酯111.8 mg/dl, pH为6.95。
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引用次数: 0
Common Problems Related to Podiatry 与足部相关的常见问题
Pub Date : 2022-01-07 DOI: 10.31579/2640-1045/108
Lk Shankhdhar, K. Shankhdhar, S. Shankhdhar
India is a developing country and lacks many things including Podiatry as subspecialty of Diabetes. There are no Podiatry Collegesnor provision for regular training of young physicians in podiatry. Missing job opportunity, kills interest of physicians in Podiatry. Most physicians have acquired some degree of skill by self-reading or doing observer ship abroad and by attending a few International conferences on Podiatry.
印度是一个发展中国家,缺乏许多东西,包括足病学作为糖尿病的亚专业。没有足病学院,也没有规定对年轻的足病医生进行定期培训。错失工作机会,扼杀了医生对足疗的兴趣。大多数医生通过自我阅读或在国外担任观察员,以及参加一些关于足病学的国际会议,获得了一定程度的技能。
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引用次数: 0
Covid-19 Pneumonia with Acute Pulmonary Embolism in a Morbidly Obese Patient; At Home Dramatic Reversal Management 病态肥胖患者新冠肺炎合并急性肺栓塞1例在家戏剧性逆转管理
Pub Date : 2022-01-07 DOI: 10.31579/2640-1045/113
Yasser Mohammed Hassanain Elsayed
Rationale: A novel COVID-19 with the severe acute respiratory syndrome had arisen in Wuhan, China in December 2019 Thromboembolism is a critical clinical entity commonly recognized sequel in COVID-19 patients. Interestingly, the presentation of COVID-19 infection with thromboembolism has a risk impact on both morbidity and mortality in COVID-19 patients. Morbid obesity may add over significant risk value in the presence of COVID-19 pneumonia with thromboembolism. Patient concerns: Middle-aged housewife female COVID-19 morbid obese patient presented to physician outpatient clinic with unilateral pneumonia suspected acute pulmonary embolism. Diagnosis: COVID-19 pneumonia with acute pulmonary embolism in morbid obesity. Interventions: CT pulmonary angiography, non- contrasted chest CT scan, electrocardiography, and oxygenation. Outcomes: Dramatic of both clinical and radiological improvement had happened. Lessons: The combination of morbid obesity, QTc prolongation with COVID-19 infection is an indicator of the over-risk of thromboembolism. It signifies the role of anticoagulants, antiplatelet, anti-infective drugs, and steroids in COVID-19 patients with unilateral pneumonia and acute pulmonary embolism in morbid obesity are effective therapies. An increasing the dose of both low-molecular heparin and oral anticoagulant with a morbidly obese patient was reasonable.
理由:2019年12月,中国武汉出现了一种新型新冠肺炎伴严重急性呼吸综合征。血栓栓塞是新冠肺炎患者公认的重要临床实体。有趣的是,新冠肺炎感染血栓栓塞对新冠肺炎患者的发病率和死亡率都有风险影响。在新冠肺炎肺炎伴血栓栓塞的情况下,病态肥胖可能会增加显著的风险值。患者关注:中年家庭主妇女性新冠肺炎病态肥胖患者因单侧肺炎疑似急性肺栓塞到医生门诊就诊。诊断:新冠肺炎合并急性肺栓塞的病态肥胖。介入治疗:CT肺动脉造影,非对比胸部CT扫描,心电图和氧合。结果:临床和放射学都有显著改善。经验教训:病态肥胖、QTc延长与新冠肺炎感染的结合是血栓栓塞风险过高的指标。这意味着抗凝血药、抗血小板药物、抗感染药物和类固醇在患有单侧肺炎和病态肥胖急性肺栓塞的新冠肺炎患者中的作用是有效的治疗方法。对于病态肥胖患者,增加低分子肝素和口服抗凝剂的剂量是合理的。
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引用次数: 0
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Endocrinology and disorders : open access
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