Antimicrobial evaluation of the Patchouli (Pogostemon cablin Benth.) leaf essential oil combination with standard antimicrobial compounds

Nazlı Şenay Beşi̇ri̇k, G. Göger
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引用次数: 1

Abstract

Pogostemon cablin Benth's leaves, which belong to the Lamiaceae family, are used to make patchouli essential oil (PEO). Sesquiterpenes are the main compounds in essential oil. Antibacterial, antifungal, antiviral, antiemetic, and anti-inflammatory activities are just a few of the many pharmacological actions that are well-known. In this investigation, cefuroxime (CEF), moxifloxacin (MOX), clarithromycin (CLA), fluconazole (FLU), and terbinafine (TER) were combined with patchouli (Pogostemon cablin leaf essential oil). Gram-positive Staphylococcus aureus ATCC 6538, Gram-negative Escherichia coli ATCC 8739, and yeasts Candida albicans ATCC 10231, and C. tropicalis ATCC 750 were tested against all combinations. Drug interaction was given as fractional inhibitory concentrations (FIC) after combinations of the essential oils were tested for their minimum inhibitory concentrations (MIC). The checkerboard method was used to assess antimicrobial interactions, Fluconazole, terbinafine, cefuroxime, and clarithromycin combined with essential oil demonstrated an "additive effect" against Candida strains together with E. coli and S. aureus.
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广藿香(Pogostemon cablin Benth.)叶精油与标准抗菌化合物组合的抗菌评价
广藿香的叶子属于Lamiaceae科,用于制作广藿香精油(PEO)。倍半萜是精油中的主要化合物。抗菌、抗真菌、抗病毒、止吐和抗炎活性只是众所周知的众多药理作用中的一小部分。在本研究中,头孢呋辛(CEF)、莫西沙星(MOX)、克拉霉素(CLA)、氟康唑(FLU)和特比萘芬(TER)与广藿香(广藿香叶精油)联合使用。针对所有组合测试革兰氏阳性金黄色葡萄球菌ATCC 6538、革兰氏阴性大肠杆菌ATCC 8739、白色念珠菌ATCC 10231和热带念珠菌ATCC 750。在测试精油组合的最低抑制浓度(MIC)后,以分数抑制浓度(FIC)给出药物相互作用。使用棋盘格法评估抗微生物相互作用,氟康唑、特比萘芬、头孢呋辛,克拉霉素与精油联合使用对念珠菌菌株、大肠杆菌和金黄色葡萄球菌具有“添加作用”。
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来源期刊
International Journal of Secondary Metabolite
International Journal of Secondary Metabolite Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
1.40
自引率
0.00%
发文量
28
期刊最新文献
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