Chitosan-Based Composite Nanosilver Gel Application in Nursing Care of Intensive Care Unit Patients with Severe Burns

Abstract

Burns are the most common clinical disease in daily life. Burn wounds are vulnerable to bacterial infection due to factors such as edema, hypoxia, and ischemia. However, traditional antibacterial supplements do not achieve satisfactory nursing results. Here, we use chitosan as a carrier by introducing silver nanoparticles (AgNPs) and recombinant human epidermal growth factor (rhEGF) together. We have constructed a new type of high moisture retention, high oxygen permeability, high-efficiency chitosan-nanosilver@recombinant human epidermal growth factor (CSAgNPs@ rhEGF) antibacterial hydrogel dressing. The clinical trials showed that the antibacterial effect of CS-AgNPs@rhEGF hydrogel dressings against Pseudomonas aeruginosa (Pa.) and Staphylococcus epidermidis (Se.) was significantly better than that of petroleum jelly and 1% silver sulfadiazine (1%-SSD). In addition, rhEGF promoted tissue cell proliferation and repair. Thus, the CS-AgNPs@rhEGF hydrogel dressing can significantly improve the wound healing rate and healing time in patients with severe burns compared with traditional dressings. Thus, CS-AgNPs@rhEGF hydrogel dressing is expected to provide a new choice for clinical burn patients to prevent wound infection and tissue repair, and has a broad prospect in burn wound healing.