Meiosis decreases recombination load; Mitosis increases recombination load

IF 0.2 Q4 EVOLUTIONARY BIOLOGY Ideas in Ecology and Evolution Pub Date : 2018-05-28 DOI:10.4033/IEE.2018.11.3.N
Root Gorelick, F. Villablanca
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引用次数: 0

Abstract

Chiasmata are necessary for proper chromosomal segregation, but can result in inadvertent recombination. Bernstein and Michod demonstrated that meiosis evolved as a means of error correction, not genetic mixing. Therefore meiotic recombination is not the sine qua non of sex, but is instead an epiphenomenon of imperfect meiotic error correction. By correcting against recombinant genotypes, meiosis reduces recombination load, thereby providing an unappreciated selective advantage for sex. Sex reducing recombination load should be integrated into population genetic models of multi-locus epistasis for maintenance of sex and may explain sequestration of germ lines in animals. We predict that eumetazoa have less recombination load than sexual organisms without a germ line. Mitosis largely lacks the error correction of meiosis, destroys linkage through ubiquitous mitotic recombination, and thereby increases recombination load, especially in co-adapted gene complexes. Meiosis and possibly karyogamy provide an unexpected benefit to sex, offsetting at least some of the famed costs of sex.
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减数分裂降低重组负荷;有丝分裂增加重组负荷
交叉是染色体分离的必要条件,但可能导致无意的重组。伯恩斯坦和米霍德证明,减数分裂的进化是一种纠错的手段,而不是基因混合。因此,减数分裂重组不是性的必要条件,而是减数分裂错误纠正不完美的副现象。通过纠正重组基因型,减数分裂减少了重组负荷,从而为性别提供了一个未被重视的选择优势。性别减少重组负荷应整合到多位点上位的群体遗传模型中,以维持性别,并可能解释动物中生殖系的隔离。我们预测真生动物比没有生殖系的有性生物有更少的重组负荷。有丝分裂在很大程度上缺乏减数分裂的纠错,通过普遍存在的有丝分裂重组破坏连锁,从而增加重组负荷,特别是在共适应基因复合体中。减数分裂和可能的核成核为性提供了意想不到的好处,至少抵消了一些著名的性成本。
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来源期刊
Ideas in Ecology and Evolution
Ideas in Ecology and Evolution EVOLUTIONARY BIOLOGY-
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0.00%
发文量
4
审稿时长
36 weeks
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