Utilidad de los biomarcadores séricos involucrados en la fisiopatología de la preeclampsia como predictores tempranos de diagnóstico

Abstract

Hypertensive disorders of pregnancy are a major contributor to death and disability for pregnant women and their infants. The diagnosis of preeclampsia using blood pressure and proteinuria is of limited use because they are tertiary, downstream features of the disease. The angiogenic factors are secondary markers of associated placental dysfunction in preeclampsia, with known low or high plasma concentrations in the disease. The aim of our article was to describe a practical panel of biomarkers useful in the early diagnosis of preeclampsia. Our conclusion is that the placental growth facto and the soluble form of tyrosine kinase 1 could be considered the 2 biomarkers with the best predictive performance, since there are more studies that evaluate their usefulness.