Prophylactic Effect of Cucumis melo on Chromium Vi-Induced Male Albino Rats

Abstract

The production of reactive oxygen species (ROS), which induce oxidative stress in humans, is linked to the negative effects of Chromium 6.The protective action of Cucumis melo L. fruit extracts was evaluated in this study in an animal model of hematological and biochemical parameters, which was induced by chromium VI (K2 Cr2 O7). The purpose of this study was to analyse the efficacy of Cucumis melo L. on chromium VI (K2 Cr2 O7)-induced rats. For 42 days, male albino rats (160–20 g) were given the stated oral LD50 dosage of chromium VI (K2Cr2O7) (10 mg/kg body weight). After 42 days, chromium-induced rats were administered with two different concentrations of Cucumis melo L. and ascorbic acid (250 mg/kg, 500 mg/kg body weight) for 7 days. Following therapy, blood was drawn and analysed for a variety of biochemical markers.The results revealed that ingestion of either plant extract, ascorbic acid, or their combination on chromium 6 induced rats significantly increase the activity of Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST) and decreased the activity of Gamma Glutamyl transferase (γ-GT) was recorded. This study has proven that fruit extract particularly its combination with ascorbic acid has a potential prophylactic effect. Cucumis melois vital for modifying the Chromium (VI) induced toxicity on male albino rats. Indeed, the recommended fruits should be consumed to the Chromium (VI) deposited harmful region since they may protect cells from environmental stress.