Is Pathogen Disgust Increased on Days of the Menstrual Cycle when Progesterone is High? Evidence from a Between-Subjects Study Using Estimated Progesterone Levels

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-12-27 DOI:10.1007/s40750-022-00208-5

Yasaman Rafiee, Benedict C. Jones, Victor Shiramizu

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引用次数: 2

Abstract

Objective

The Compensatory Prophylaxis Hypothesis proposes that women will show increased pathogen disgust at points in the menstrual cycle when progesterone is high, compensating for the immunosuppressive effects of progesterone. However, evidence for the Compensatory Prophylaxis Hypothesis from studies that used longitudinal designs to investigate whether pathogen disgust tracks changes in progesterone is mixed. It was recently proposed that longitudinal designs may be poorly suited to testing the Compensatory Prophylaxis Hypothesis because carry-over effects when women are tested repeatedly in within-subject designs might obscure the effects of progesterone and pathogen disgust. Consequently, we used a between-subjects design to test for a positive relationship between scores on the pathogen disgust subscale of the Three Domain Disgust Scale and progesterone levels imputed from menstrual cycle data using actuarial tables.

Methods

We employed a between-subject design on N = 1346 women using the Three Domains of Disgust Scale (TDDS).

Results

We found no evidence for a positive effect of progesterone on pathogen disgust, suggesting that null results for the hypothesized relationship between progesterone and pathogen disgust are not limited to studies using designs that may be subject to carry-over effects caused by repeated testing.

Conclusion

Our results add to a growing body of research that does not support the Compensatory Prophylaxis Hypothesis.

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当孕酮水平高时，对病原体的厌恶感是否会增加?使用估计孕酮水平的受试者间研究证据

目的补偿性预防假说提出，女性在月经周期中孕酮水平高时，会表现出对病原体的厌恶感增加，从而补偿孕酮的免疫抑制作用。然而，使用纵向设计来调查病原体厌恶是否跟踪孕酮变化的研究中，补偿预防假说的证据是混合的。最近有人提出，纵向设计可能不适合测试补偿预防假说，因为在受试者内部设计中反复测试女性时的遗留效应可能会掩盖孕酮和病原体厌恶的影响。因此，我们使用受试者之间的设计来测试三域恶心量表的病原体厌恶分量表得分与使用精算表从月经周期数据估算的孕酮水平之间的正相关关系。方法采用N = 1346名女性使用三个厌恶领域量表（TDDS）。结果我们没有发现孕酮对病原体厌恶有积极影响的证据，这表明孕酮和病原体厌恶之间假设关系的无效结果并不局限于使用可能会因重复测试而产生结转影响的设计的研究。结论我们的研究结果增加了越来越多的不支持补偿预防假说的研究。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.