The supplementation with Resveratrol and α-Tocopherol could reduce the risk of sarcopenia in dogs by counteracting the oxidative stress

Abstract

. Several scientific evidences show that oxidative stress is associated with the origin, progression and severity of chronic noncommunicable diseases. Due to the longer duration of life, sarcopenia, osteopenia, osteoporosis and cachexia are considered emerging syndromes for dogs and cats. The objective was to investigate the impact of a supplementation with resveratrol and (cid:2) -tocopherol (JUVENIA ® ) on the harmful effects of oxidative stress in adult dogs. The study was able to demonstrate this supplementation was able to positively modulate creatine phosphokinase and alkaline phosphatase, which are considered useful biomarkers for sarcopenia, bone formation and speed in bone remodeling. As a result of the longer life of domestic animals and, in particular dogs, the use of food supplements with antioxidant activity could play a critical role in reducing/delaying the onset of chronic-degenerative diseases. On the basis of the present study, the use of products containing resveratrol and (cid:2) -tocopherol acetate seems to be a promising approach for improving the health of dogs. mentation, there was a statistically significant reduction of serum concentrations of alkaline phosphatase These values returned to baseline after a further 45 days of basal diet without supplementation (control). Also, in this case the increase was statistically significant, while no difference was observed between baseline and data at day 90, (see Table 2).