The FTO Gene rs9939609 Polymorphism and its Association with BAI as Well as Other Adiposity Markers

Abstract

The FTO Gene rs9939609 Polymorphism and its Association with BAI as Well as Other Adiposity Markers. Abstract Introduction: The Fat mass and obesity associated (FTO) rs9939609 gene polymorphism has been studied in many parts of the world to find its implication on obesity and Type 2 diabetes mellitus. Objective: The present study is conducted to find out the association of FTO gene polymorphism with adiposity markers among the adult population of North Delhi. Materials and Method: Anthropometric measurements and intravenous blood sample were collected from 247 individuals who were residing in Delhi for more than 15 years. Informed written consent was also taken before conducting the study from each individual. DNA (Deoxyribose Nucleic Acid) isolation and genotyping were carried out using standard protocol. Statistical analysis was done using SPSS version 17.0. Results: Maximum mean of waist circumference, body mass index and conicity index are found to be associated with the risk genotype of FTO marker. Conclusion: This study revealed the difference in the prediction of FTO genotypes on different adiposity markers.