{"title":"Development of 3D-Printed Magnetic Micro-Nanorobots for Targeted Therapeutics: the State of Art","authors":"Ningning Hu, Lujia Ding, Yuyi Liu, Kemin Wang, Bing Zhang, Ruixue Yin, Wenju Zhou, Zhuming Bi, Wenjun Zhang","doi":"10.1002/anbr.202300018","DOIUrl":null,"url":null,"abstract":"<p>Micro-/nanorobots (mn-robots), inspired by the versatile mechanisms found in natural microorganisms, show great potential in enabling innovative bio-applications. The 3D-printed magnetic mn-robots are substantially advanced to swim in vivo and to carry and release therapeutic agents in a controlled manner. To understand the state of the art of such robots and identify their development trend, this article presents a comprehensive and systematic review of the recent works on development of magnetic robots and their applications in biomedical engineering, with a particular focus on targeted therapeutic delivery. The developments in materials, fabrications, actuations, and applications with design for magnetic mn-robots are reviewed, and it is aimed to discover the limitations of the existing works and to identify the knowledge gap, thereby deriving future research directions on developing magnetic mn-robots, especially for their applications in targeted therapeutic delivery.</p>","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"3 10","pages":""},"PeriodicalIF":4.0000,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300018","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Nanobiomed Research","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/anbr.202300018","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Micro-/nanorobots (mn-robots), inspired by the versatile mechanisms found in natural microorganisms, show great potential in enabling innovative bio-applications. The 3D-printed magnetic mn-robots are substantially advanced to swim in vivo and to carry and release therapeutic agents in a controlled manner. To understand the state of the art of such robots and identify their development trend, this article presents a comprehensive and systematic review of the recent works on development of magnetic robots and their applications in biomedical engineering, with a particular focus on targeted therapeutic delivery. The developments in materials, fabrications, actuations, and applications with design for magnetic mn-robots are reviewed, and it is aimed to discover the limitations of the existing works and to identify the knowledge gap, thereby deriving future research directions on developing magnetic mn-robots, especially for their applications in targeted therapeutic delivery.
期刊介绍：
Advanced NanoBiomed Research will provide an Open Access home for cutting-edge nanomedicine, bioengineering and biomaterials research aimed at improving human health. The journal will capture a broad spectrum of research from increasingly multi- and interdisciplinary fields of the traditional areas of biomedicine, bioengineering and health-related materials science as well as precision and personalized medicine, drug delivery, and artificial intelligence-driven health science.
The scope of Advanced NanoBiomed Research will cover the following key subject areas:
▪ Nanomedicine and nanotechnology, with applications in drug and gene delivery, diagnostics, theranostics, photothermal and photodynamic therapy and multimodal imaging.
▪ Biomaterials, including hydrogels, 2D materials, biopolymers, composites, biodegradable materials, biohybrids and biomimetics (such as artificial cells, exosomes and extracellular vesicles), as well as all organic and inorganic materials for biomedical applications.
▪ Biointerfaces, such as anti-microbial surfaces and coatings, as well as interfaces for cellular engineering, immunoengineering and 3D cell culture.
▪ Biofabrication including (bio)inks and technologies, towards generation of functional tissues and organs.
▪ Tissue engineering and regenerative medicine, including scaffolds and scaffold-free approaches, for bone, ligament, muscle, skin, neural, cardiac tissue engineering and tissue vascularization.
▪ Devices for healthcare applications, disease modelling and treatment, such as diagnostics, lab-on-a-chip, organs-on-a-chip, bioMEMS, bioelectronics, wearables, actuators, soft robotics, and intelligent drug delivery systems.
with a strong focus on applications of these fields, from bench-to-bedside, for treatment of all diseases and disorders, such as infectious, autoimmune, cardiovascular and metabolic diseases, neurological disorders and cancer; including pharmacology and toxicology studies.
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