The case-control study on relationship between the serum concentration of IL-7 and the pathogenesis of psoriasis: ampere systematic review and meta-Analysis

Pub Date : 2023-04-07 DOI:10.1177/1721727x231160361
Jiandong Liu, Linxi Zeng, Xin Huang, Lu Liu, Nana Guo, Jinfang Zhang, G. Zhang
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Abstract

To explore the relationship between the serum concentration of IL-17 and the pathogenesis of psoriasis. ampere database was established through literature search, and meta-analysis was used to evaluate the effect indicator of the included literatures. 5 articles were included in the study, and the quality evaluation score was 6–7 points by the Newcastle-Ottawa Scale (NOS) criteria. There was heterogeneity in the standardized mean difference (SMD) between the two groups (I2 = 98.63%). The random effect model analysis showed that the combined SMD = 2.11, 95%CI (0.79, 3.43), the effect size between studies was statistically significant (z = 3.13, p = 0.00). There was a statistical difference in serum IL-17 concentration between the case group and the control group. The serum concentration of IL-17 in the case group was higher than that in the control group.
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血清IL-7浓度与银屑病发病关系的病例对照研究:安培系统回顾与荟萃分析
探讨血清IL-17浓度与银屑病发病机制的关系。通过文献检索建立amper数据库,并采用meta分析对纳入文献的效果指标进行评价。研究中包括5篇文章,根据纽卡斯尔-渥太华量表(NOS)标准,质量评估得分为6-7分。两组间的标准化平均差(SMD)存在异质性(I2=98.63%)。随机效应模型分析显示,组合SMD=2.11,95%CI(0.79,3.43),研究之间的效应大小具有统计学意义(z=3.13,p=0.00)。病例组和对照组之间的血清IL-17浓度存在统计学差异。病例组血清IL-17浓度明显高于对照组。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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