Putative anti-proliferative effect of Indian mustard (Brassica juncea) seed and its nano-formulation

IF 3.8 4区工程技术 Q2 CHEMISTRY, MULTIDISCIPLINARY Green Processing and Synthesis Pub Date : 2023-01-01 DOI:10.1515/gps-2022-8119

P. Virk, M. Awad, M. Alanazi, A. Hendi, M. Elobeid, K. Ortashi, A. W. Alrowaily, Taghreed Bahlool, F. Aouaini

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Abstract

Abstract Over the past few decades, nanotechnology has shown promising prospects in biomedicine and has a proven impact on enhancing therapeutics by facilitating drug delivery. The present study brings an amalgamation of nanoscience and “clean technology” by fabricating nature-friendly nanoparticles (NPs) sans the use of chemical surfactants using Indian mustard seed, Brassica juncea L. The as-synthesized NPs were characterized to assess their average size, crystallinity, morphology, and constituent functional groups through conventional techniques: dynamic light scattering (DLS), X-ray diffraction (XRD), scanning electron microscopy (SEM), and Fourier-transform infrared spectroscopy (FTIR). The NPs were crystalline in nature and exhibited a mean size of 205.5 nm (PDI of 0.437) being primarily polygonal in shape. Additionally, the therapeutic efficacy of the green NPs was evaluated based on their cytotoxic effect against two human cancer lines, MCF-7 and HepG-2. Both the NPs and the bulk seeds showed a dose-dependent cytotoxic effect. However, an assessment of the antiproliferative/cytotoxic potential of the green NPs versus the bulk seeds showed that the NPs were relatively more efficacious on both cell lines. Taken together, the mustard seed NPs could be potential nutraceuticals considering the green credential in their mode of biosynthesis.

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芥菜种子及其纳米制剂的抗增殖作用

摘要在过去的几十年里，纳米技术在生物医学中显示出了很有前途的前景，并通过促进药物递送对增强治疗具有重要影响。本研究通过使用印度芥菜籽芸苔属（Brassica juncea L.）在不使用化学表面活性剂的情况下制备对自然友好的纳米颗粒（NP），实现了纳米科学和“清洁技术”的融合，通过常规技术：动态光散射（DLS）、X射线衍射（XRD）、扫描电子显微镜（SEM）和傅里叶变换红外光谱（FTIR）来确定组成官能团。NP本质上是结晶的，并且显示出205.5的平均尺寸 nm（PDI为0.437）主要为多边形。此外，基于绿色NP对两种人癌症细胞系MCF-7和HepG-2的细胞毒性作用来评估其治疗效果。NP和散装种子都显示出剂量依赖性的细胞毒性作用。然而，与散装种子相比，对绿色NP的抗增殖/细胞毒性潜力的评估表明，NP对两种细胞系都相对更有效。综合来看，考虑到其生物合成模式中的绿色证书，芥末籽NP可能是潜在的营养品。

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来源期刊

Green Processing and Synthesis CHEMISTRY, MULTIDISCIPLINARY-ENGINEERING, CHEMICAL

CiteScore

6.70

自引率

9.30%

发文量

审稿时长

7 weeks

期刊介绍： Green Processing and Synthesis is a bimonthly, peer-reviewed journal that provides up-to-date research both on fundamental as well as applied aspects of innovative green process development and chemical synthesis, giving an appropriate share to industrial views. The contributions are cutting edge, high-impact, authoritative, and provide both pros and cons of potential technologies. Green Processing and Synthesis provides a platform for scientists and engineers, especially chemists and chemical engineers, but is also open for interdisciplinary research from other areas such as physics, materials science, or catalysis.